Ventilation and breathing patterns during hemodialysis-induced carbon dioxide unloading

The American Review of Respiratory Disease
W A De BackerM E De Broe


Important CO2 unloading occurs during hemodialysis (HD) when acetate-buffered dialysate is used. This is accompanied by alveolar hypoventilation. To gain more insight into the mechanisms of this alveolar hypoventilation, breathing patterns were studied in 5 patients with end-stage renal failure during HD using acetate-buffered dialysate, which induces CO2 unloading, or bicarbonate without CO2 loss. Ventilation was continuously measured with calibrated respiratory inductance plethysmography using techniques of multiple linear regression analysis. At regular intervals, arterial blood gas was sampled and expired air was analyzed. Breathing patterns were analyzed for VE, VT, TI, TE, and VT/TI. All data were compared with the respective starting value and with the respective value in the other setup. A greater decrease in ventilation was seen during HD with an acetate-containing dialysate because of irregular breathing patterns that resulted in a prolongation of expiratory time. Important variations in tidal volumes, striking apnea periods, and occasional periodic breathing were observed. We suggest that these irregularities are due to CO2 unloading leading to the point where ventilation is totally mediated through the output of the...Continue Reading


Oct 1, 1979·Archives of Internal Medicine·F Dumler, N W Levin
Apr 7, 1977·The New England Journal of Medicine·P R CraddockH S Jacob
Jan 1, 1986·Respiration; International Review of Thoracic Diseases·T H RossingJ W Weiss
Jan 1, 1986·Nephron·R R LinsM E De Broe
Jan 1, 1985·American Journal of Nephrology·M J GermainJ P Fitzgibbons
Jan 1, 1984·Respiration Physiology·A BerkenboschP H Quanjer
Jan 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·E A PhillipsonJ D Cooper
Sep 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M C KhooA S Slutsky


Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·J MercierC Préfaut
Apr 7, 2006·Lung·Nikolaos MarkouStavros Konstantopoulos
Sep 1, 2000·Respiration Physiology·M C Khoo
Dec 19, 1998·Respiration Physiology·W De Backer
Sep 1, 1991·European Journal of Pediatrics·K PaulK Schärer
Dec 10, 1991·Clinical Materials·R Vanholder
Sep 12, 2015·Seminars in Nephrology·Sushma M DhariaLee K Brown
Jun 5, 2014·BioMed Research International·Anastasios F PalamidasNikolaos G Koulouris

Related Concepts

Carbon Dioxide
Hydrogen-Ion Concentration

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.