Ventilation Heterogeneity in Never-smokers and COPD:: Comparison of Pulmonary Functional Magnetic Resonance Imaging with the Poorly Communicating Fraction Derived From Plethysmography

Academic Radiology
Christopher DavisCanadian Respiratory Research Network

Abstract

Pulmonary functional magnetic resonance imaging provides a way to quantify ventilation and its heterogeneity-a hallmark finding in chronic obstructive pulmonary disease (COPD). Unfortunately, the etiology and physiological meaning of ventilation defects and their relationship to pulmonary function and symptoms in COPD are not well understood. Another biomarker of ventilation heterogeneity is provided by the "poorly communicating fraction" (PCF), and is calculated as the ratio of total lung capacity to alveolar volume made using whole-body plethysmography. Our objective was to compare ventilation heterogeneity using hyperpolarized (3)He magnetic resonance imaging (MRI) and PCF measurements in elderly never-smokers and in ex-smokers with COPD. One hundred forty-six participants (71 ± 8 years, range = 48-87 years) provided written informed consent including 45 elderly never-smokers (71 ± 6 years, range = 61-84 years) and 101 ex-smokers with COPD (71 ± 8 years, range = 48-87 years). During a single 2-hour visit, spirometry, plethysmography, and hyperpolarized (3)He MRI were acquired. The MRI-derived ventilation defect percent (VDP) and plethysmography measurements were acquired and PCF values were calculated. Linear regression, Pea...Continue Reading

References

Mar 1, 1986·Journal of Thoracic Imaging·A SantolicandroC Giuntini
Dec 24, 1998·The European Respiratory Journal·M J MorrisD J Lane
Mar 5, 1999·The European Respiratory Journal·D E Leith, R Brown
Sep 30, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·X J ChenG A Johnson
Mar 22, 2005·Journal of Magnetic Resonance Imaging : JMRI·Neil WoodhouseEdwin J R van Beek
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Sep 2, 2005·The European Respiratory Journal·J WangerG Viegi
Oct 6, 2005·The European Respiratory Journal·N MacintyreJ Wanger
Feb 10, 2006·Physics in Medicine and Biology·Thomas GuerreroRitsuko Komaki
Jun 27, 2006·American Journal of Respiratory and Critical Care Medicine·Sylvia VerbanckWalter Vincken
Jan 25, 2008·The European Respiratory Journal·J VestboUNKNOWN ECLIPSE investigators
Jun 23, 2009·The European Respiratory Journal·E J R van BeekH-U Kauczor
Jul 18, 2009·American Journal of Respiratory and Critical Care Medicine·Harvey O CoxsonDon D Sin
Mar 27, 2010·Annals of Nuclear Medicine·Kazuyoshi SugaNaofumi Matsunaga
Nov 23, 2011·Academic Radiology·Miranda KirbyGrace Parraga
Sep 14, 2013·Thorax·David CouperUNKNOWN SPIROMICS Research Group
Aug 12, 2014·The European Respiratory Journal·Kim HusemannMartin Kohlhäufl

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Citations

May 27, 2017·Expert Review of Respiratory Medicine·Amany F ElbehairyUNKNOWN Canadian Respiratory Research Network (CRRN)
Mar 28, 2017·Annals of the American Thoracic Society·J Alberto NederUNKNOWN Canadian Respiratory Research Network
Mar 10, 2017·The European Respiratory Journal·Gisele Walter BarbosaPaulo de Tarso Müller
Mar 14, 2019·Annals of the American Thoracic Society·Surya P BhattArie Nakhmani
Sep 12, 2019·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·José Alberto NederDenis E O'Donnell

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