Ventilation-induced pulmonary vasodilatation in lambs with congenital diaphragmatic hernia is modulated by nitric oxide

Experimental Lung Research
A S de Buys RoessinghA T Dinh-Xuan

Abstract

Endogenous nitric oxide (NO) mediates pulmonary vasodilatation at birth, but inhaled NO fails to reduce pulmonary vascular resistance (PVR) in newborns with congenital diaphragmatic hernia (CDH). This study was designed to investigate the effects of ventilation, and the nature of its endogenous mediator, in fetal lambs with experimental CDH. Investigations at 138 days of gestation showed that ventilation markedly decreased PVR. Inhibition of NO synthesis reduced ventilation-induced pulmonary vasodilatation in vivo and increased in vitro isometric tension of vascular rings. Ventilation therefore reduces PVR at birth in lambs with CDH, and endogenous NO seems to contribute to this reduction.

References

Aug 1, 1991·Pediatric Research·T M Zellers, P M Vanhoutte
Jan 1, 1988·Proceedings of the Society for Experimental Biology and Medicine·F J Accurso, R B Wilkening
Feb 1, 1984·Journal of Pediatric Surgery·R T SoperJ C Scofield
Apr 1, 1984·Journal of Pediatric Surgery·K C PringleR T Soper
Aug 1, 1995·American Journal of Respiratory Cell and Molecular Biology·J K WardM G Belvisi
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·F C Morin, K R Stenmark
Jun 1, 1994·The Journal of Clinical Investigation·J R FinemanS J Soifer
Feb 1, 1993·The American Journal of Physiology·H BirnE I Christensen
Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·J A ScottD G McCormack
Aug 1, 1996·European Journal of Pediatrics·T H Shaffer, M R Wolfson
Jan 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·R L RairighS H Abman
Mar 4, 2000·The European Respiratory Journal·M LévyA T Dinh-Xuan
Jan 11, 2001·Histochemistry and Cell Biology·C TzaoR H Steinhorn
Jun 19, 2001·The European Respiratory Journal·R A VeldhuizenL McCaig
Oct 26, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Boaz OvadiaJeffrey R Fineman
Jan 1, 2003·The Journal of Comparative Neurology·Randal P BabiukJohn J Greer
Jun 27, 2003·American Journal of Physiology. Cell Physiology·Shampa ChatterjeeAron B Fisher
May 1, 1964·The Journal of Physiology·S CASSINL B STRANG
Nov 17, 2004·The Journal of Pathology·Pascal de LagausieDominique Berrebi

❮ Previous
Next ❯

Citations

Sep 10, 2008·Journal of Pediatric Surgery·Julia MorinisJacob C Langer
Nov 25, 2017·Seminars in Fetal & Neonatal Medicine·Francesca Maria RussoJan Deprest

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.