Ventilation-induced pulmonary vasodilation at birth is modulated by potassium channel activity

The American Journal of Physiology
M Tristani-FirouziD N Cornfield

Abstract

At birth, pulmonary blood flow rapidly increases 8- to 10-fold, and pulmonary arterial pressure falls by 50% within 24 h. The postnatal adaptation of the pulmonary circulation is mediated, in part, by endothelium-derived nitric oxide (EDNO). Recent studies suggest that EDNO may reduce vascular resistance, in part, by activating K+ channels. We hypothesized that K+ channels modulate the changes in pulmonary hemodynamics associated with birth. To test this hypothesis, we studied the effect of K+ channel inhibition on two separate, but interdependent stimuli: 1) mechanical ventilation with low inspired O2 concentrations (designed to maintain normal fetal blood gas tensions) and 2) mechanical ventilation with high inspired O2 concentrations. Tetraethyl-ammonium (TEA, 1 mg/min for 100 min; n = 5), a nonspecific K+ channel blocker, glibenclamide (Gli, 1 mg/min for 30 min; n = 6), an ATP-sensitive K+ channel blocker, or saline (n = 7) was infused into the left pulmonary artery (LPA) of acutely instrumented fetal lambs. The umbilical-placental circulation remained intact, and lambs were ventilated with 0.10 inspired O2 concentration (FIO2) for 60 min, followed by 1.0 FIO2 for 20 min. Neither TEA nor Gli had an effect on basal pulmonary...Continue Reading

Citations

Jun 3, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·D N CornfieldH L Reeve
Oct 29, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·D N CornfieldS H Abman
Feb 10, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ernesto ResnikDavid N Cornfield
Aug 17, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Cristina M AlviraDavid N Cornfield
Nov 25, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yong-Tae AhnDavid N Cornfield
Sep 23, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·V A PorterD N Cornfield
Oct 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrea OlschewskiDavid N Cornfield
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y TakahashiM A Heymann
Jul 29, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bradley C LindenDavid N Cornfield
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·David N CornfieldJeffrey R Fineman
Dec 8, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carla Blum-JohnstonSean M Wilson
May 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·M T RhodesD N Cornfield
Apr 13, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elizabeth A BarnesDavid N Cornfield
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
Nov 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·V A PorterD N Cornfield
Nov 15, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ernesto ResnikDavid N Cornfield
Oct 21, 2010·Physiological Reviews·Yuansheng Gao, J Usha Raj

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