Ventilation-perfusion abnormalities in the preterm infant with hyaline membrane disease: a two-compartment model of the neonatal lung

Pediatric Pulmonology
I L HandP A Auld

Abstract

Arterial-alveolar differences for oxygen, carbon dioxide, and nitrogen were measured in 7 non-distressed preterm infants and 21 ventilator-dependent preterm infants with hyaline membrane disease. The preterm infants with hyaline membrane disease had a significantly lower average arterial pH (7.34 vs. 7.44; P less than 0.001), and significantly higher arterial-alveolar differences for oxygen (286 mm Hg vs. 34 mm Hg; P less than 0.005) and nitrogen (118 mm Hg vs. 7 mm Hg; P less than 0.005). Both groups had elevated arterial-alveolar differences for PCO2 (9 mm Hg in infants with hyaline membrane disease, 5 mm Hg in nondistressed infants; P less than 0.2). When acute changes in mean airway pressure were produced in 14 distressed infants, arterial-alveolar CO2 and N2 differences moved in opposite directions in 11 infants. This observation suggests that changes in mean airway pressure do not acutely recruit atelectatic alveoli, but cause redistribution of ventilation within alveoli already ventilated.

References

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Citations

Jan 1, 1990·Pediatric Pulmonology·W A Hodson
Aug 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·H L Smith, J G Jones
Nov 26, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·J G JonesB J Stenson
Dec 18, 2018·Frontiers in Physiology·Michaël SageÉtienne Fortin-Pellerin

Related Concepts

Carbon Dioxide
Hyaline Membrane Disease
Hydrogen-Ion Concentration
Neonatal Prematurity
Nitrogen
Dioxygen
Pulmonary Gas Exchange
Ventilation-Perfusion Ratio

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