PMID: 7800432Sep 1, 1994Paper

Ventilation-perfusion relationships in preterm infants after surfactant treatment

Pediatric Pulmonology
W BowenP A Auld

Abstract

Arterial-alveolar partial pressure differences for oxygen, carbon dioxide, and nitrogen were measured before and after surfactant replacement therapy on 15 occasions in 14 ventilator-dependent preterm infants with hyaline membrane disease (HMD). Eight treatments resulted in a significant improvement in arterial partial pressure of oxygen (PaO2) 2 hr after treatment; 7 did not. Neither group showed any significant change in arterial-alveolar partial pressure differences for oxygen, nitrogen, and carbon dioxide. This observation suggests that if surfactant replacement therapy produces an improvement in PaO2 it does so by recruitment of atelectatic alveoli with a balanced ventilation/perfusion ratio rather than by redistribution of ventilation within already ventilated alveoli.

References

Jan 1, 1975·Journal of Applied Physiology·A CorbetL Stern
Feb 1, 1978·Archives of Disease in Childhood·W L HolmanP A Auld
Jan 1, 1985·Clinical Physiology·C FrostellR Cronestrand
Feb 1, 1973·Pediatric Research·C A ToriP A Auld
Jan 1, 1974·Journal of Applied Physiology·A CorbetL Stern
May 1, 1969·Pediatric Research·A N Krauss, P A Auld
Dec 1, 1967·The Journal of Pediatrics·D W ThibeaultP A Auld
Jan 1, 1963·Journal of Applied Physiology·L E FARHIT HOMMA

Citations

Sep 26, 2001·Clinics in Perinatology·G K Suresh, R F Soll

Related Concepts

Survanta
Biological Products
Carbon Dioxide
Hyaline Membrane Disease
Dioxygen
Pulmonary Alveolar Structure
Pulmonary Gas Exchange
Pulmonary Surfactants
Ventilation-Perfusion Ratio

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