Ventilation strategy affects cytokine release after mesenteric ischemia-reperfusion in rats

Critical Care Medicine
Lila BouadmaGeorges Saumon

Abstract

To evaluate the impact of different ventilation modalities on lung and plasma concentrations of cytokines in a model of secondary lung inflammation, mesenteric ischemia-reperfusion, in rats. Prospective, randomized, controlled animal study. Research laboratory of a university. Sixty-four male adult Wistar rats weighing 320-380 g. Eight groups were studied. Two groups underwent no surgical procedure: They were either not ventilated or ventilated with an injurious modality consisting of 30 mL/kg tidal volume (Vt) without positive-end expiratory pressure (PEEP). Animals of the other groups underwent laparotomy with or without 2-hr mesenteric ischemia followed by 4 hrs of reperfusion during which the rats were mechanically ventilated. Ventilation modalities were conventional (tidal volume 10 mL/kg, PEEP 3 cm H2O), protective (6 mL/kg, 6 cm H(2)O), or injurious (tidal volume 30 mL/kg and no PEEP). Rats were killed by exsanguination, and their lungs were excised and homogenized in buffer. Supernatants of lung homogenates and plasmas were stored at -80 degrees C for subsequent measurements. Tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, macrophage inhibitory protein 2, and interleukin-10 were determined in lung supern...Continue Reading

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Oct 31, 2012·Intensive Care Medicine·Francois Lellouche, Jed Lipes
Apr 20, 2013·Pediatric Research·Merih CetinkayaS Umit Sarici
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