PMID: 8944583Nov 1, 1996Paper

Ventilation/carbon dioxide production ratio in early exercise predicts poor functional capacity in congestive heart failure

Heart
R V MilaniH O Ventura

Abstract

To evaluate whether changes in the ventilation/carbon dioxide production ratio during early exercise could reliably serve as a surrogate marker for maximal oxygen consumption in heart failure patients. Maximal oxygen consumption is an important determinant of the severity of congestive heart failure with values > 14 ml/kg/min conferring a good 2-year survival. However, many patients undergoing cardiopulmonary exercise testing cannot exercise maximally because of other functional limitations. Ventilation/carbon dioxide production ratio was assessed at rest, anaerobic threshold, and peak exercise in 75 patients with chronic heart failure and in 12 healthy controls. Patients were divided into two groups on the basis of heart failure severity as judged by maximal oxygen consumption. Patients with mild-moderate heart failure had a 20% reduction in the ventilation/carbon dioxide production ratio at anaerobic threshold similar to that in healthy controls. Patients with severe heart failure failed to reduce this ratio at anaerobic threshold. Furthermore, a reduction in the ventilation/carbon dioxide production ratio in early exercise of less than 10% predicted a maximal oxygen consumption of < 14 ml/kg/min with a positive predictive va...Continue Reading

References

May 1, 1992·Circulation·H DrexlerH Just
Nov 15, 1992·Journal of the American College of Cardiology·A L ClarkA J Coats
May 1, 1991·Journal of the American College of Cardiology·J MyersV F Froelicher
Jan 11, 1985·The American Journal of Cardiology·K T Weber, J S Janicki
Feb 1, 1984·The American Review of Respiratory Disease·B J WhippK Wasserman

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Citations

Dec 29, 2000·Journal of the American College of Cardiology·A F OsmanR V Milani
Nov 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G A MacGowanS Murali
Jun 30, 2009·Journal of Cardiopulmonary Rehabilitation and Prevention·Joseph F NormanSteven K Krueger
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·J A NederB J Whipp
Sep 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideki TsurugayaKoichi Taniguchi
Mar 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Akihisa MiyazakiMasahiko Kurabayashi
Dec 9, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ross ArenaMarco Guazzi
Dec 15, 2006·Mayo Clinic Proceedings·Richard V MilaniHector O Ventura
Jul 15, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Chul-Ho KimBruce D Johnson
Mar 5, 2004·The American Journal of Cardiology·Carl J LavieMandeep R Mehra
Jul 28, 2004·Circulation·Richard V MilaniMandeep R Mehra
May 7, 2002·Evolution; International Journal of Organic Evolution·John M PandolfiAnn F Budd

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