Ventilation/perfusion ratio and right to left shunt in healthy newborn infants

Journal of Clinical Monitoring and Computing
Theodore DassiosAnne Greenough


Oxygenation impairment can be assessed non-invasively by determining the degree of right-to-left shunt and ventilation/perfusion (VA/Q) inequality. These indices have been used in sick newborn infants, but normative values have not been reported which are essential to determine the magnitude of the abnormality. We, therefore, aimed to measure the shunt and VA/Q in infants with no history of respiratory conditions and determine if there was any effect of supine or prone position and the reproducibility of the data. Data were analysed from infants who had undergone a hypoxic challenge and in a subset who had been assessed in the supine or prone position. Transcutaneous oxygen saturations (SpO2) were recorded at fractions of inspired oxygen (FIO2) of 0.21 and 0.15. Two independent raters used a computer software algorithm which analysed and fitted paired data for FIO2 and SpO2 and derived a curve which represented the best fit for each infant's data and calculated the shunt and VA/Q. The raters ability to interpret the SpO2 value which corresponded to a given FIO2 was compared. The downwards displacement of the FIO2 versus SpO2 curve was used to estimate the degree of right-to-left shunt and the rightwards shift of the curve was u...Continue Reading


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Jan 10, 2014·Journal of Clinical Monitoring and Computing·Geoffrey G LockwoodJ Gareth Jones
Feb 26, 2015·Annals of the American Thoracic Society·Nicolas BamatHaresh Kirpalani
Sep 28, 2015·Respiratory Physiology & Neurobiology·Theodore DassiosRobert Ross-Russell
Nov 26, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·J G JonesB J Stenson

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May 14, 2018·Acta Paediatrica·Emma WilliamsAnne Greenough
Feb 27, 2018·Journal of Clinical Monitoring and Computing·D S KarbingM B Jaffe
Feb 23, 2019·American Journal of Respiratory and Critical Care Medicine·Jenny SvedenkransJ Jane Pillow
Apr 16, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Theodore DassiosAnne Greenough

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