Ventilatory and cardiovascular actions of centrally and peripherally administered trout pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) in the unanaesthetized trout

The Journal of Experimental Biology
J-C Le MévelJ M Conlon

Abstract

In mammals, pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are involved in cardiovascular and respiratory regulation. Several studies have demonstrated the presence of PACAP, VIP and their receptors in various tissues of teleost fish, including the brain, but little is known about their respiratory and cardiovascular effects. The present study was undertaken to compare the central and peripheral actions of graded doses (25-100 pmol) of trout PACAP and trout VIP on ventilatory and cardiovascular variables in the unanaesthetized rainbow trout. Compared with vehicle, only intracerebroventricular injection of PACAP significantly (P<0.05) elevated the ventilation frequency and the ventilation amplitude, but both peptides significantly increased the total ventilation (total ventilation). However, the maximum hyperventilatory effect of PACAP was approximately 2.5-fold higher than the effect of VIP at the 100 pmol dose (PACAP, (total ventilation)=+5407+/-921 arbitrary units, a.u.; VIP, (total ventilation)=+2056+/-874 a.u.; means +/- s.e.m.). When injected centrally, only PACAP produced a significant increase in mean dorsal aortic blood pressure (P(DA)) (100 pmol: +21%) but neither pep...Continue Reading

References

Jan 18, 2002·Journal of Applied Physiology·S O MackM A Haxhiu
Oct 19, 2002·Respiratory Physiology & Neurobiology·Prabha KcSerdia O Mack
Feb 27, 2003·The Journal of Experimental Biology·J Turesson, L Sundin
Oct 2, 2003·Respiratory Physiology & Neurobiology·L SundinM Burleson
Sep 4, 2007·The Journal of Experimental Biology·Jean-Claude Le MévelJ Michael Conlon
Feb 15, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melissa M J FarnhamPaul M Pilowsky
Jul 1, 2008·Respiratory Physiology & Neurobiology·Richard J A Wilson, Kevin J Cumming

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Citations

Dec 12, 2013·Respiratory Physiology & Neurobiology·Marc KermorgantJean-Claude Le Mével
Apr 1, 2014·General and Comparative Endocrinology·Marc KermorgantJean-Claude Le Mével
Jun 15, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Frédéric LancienJean-Claude Le Mével
May 11, 2012·The Journal of Experimental Biology·Jean-Claude Le MévelJ Michael Conlon

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