PMID: 6132819Jan 1, 1983

Ventilatory and haemodynamic effects of prenalterol and terbutaline in asthmatic patients

European Journal of Clinical Pharmacology
A P Greefhorst, C L van Herwaarden

Abstract

In 8 asthmatic patients a comparative study was performed of the ventilatory and haemodynamic effects of the beta 1-receptor stimulator prenalterol and the beta 2-receptor stimulator terbutaline infused in increasing doses after a placebo. Terbutaline caused a dose-dependent decrease in diastolic blood-pressure (BP) and an increase in systolic BP and heart-rate (HR), while mean arterial pressure (MAP) did not change. Prenalterol produced a dose-dependent increase in MAP and systolic BP, while diastolic BP was unaffected. HR was increased only by the largest dose of prenalterol. The haemodynamic effects of the terbutaline infusion can be explained by a reflex response to the vasodilatation induced by stimulation of the vascular beta 2-receptors, while the effects of prenalterol can mainly be accounted for by a direct action on beta 1-receptors in the heart. These observations show that the cardiac side-effects of beta 2-agonists cannot be avoided by producing more selective agonists. Terbutaline caused a dose-dependent increase in the ventilatory indices. Prenalterol in larger doses caused a limited but significant increase in the ventilatory indices, comparable to the decrease in ventilation caused by the beta 1-selective block...Continue Reading

References

Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Apr 1, 1979·British Journal of Clinical Pharmacology·D H ScottD B Scott
Oct 1, 1979·British Journal of Diseases of the Chest·C K Connolly
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·U Johansson, B Waldeck
Jan 1, 1981·European Journal of Clinical Pharmacology·A P Greefhorst, C L van Herwaarden
Apr 16, 1982·Journal of Chromatography·M ErvikP O Lagerström
Jun 1, 1980·Biomedical Mass Spectrometry·S E JacobssonL Svensson

Citations

Nov 1, 1986·British Journal of Clinical Pharmacology·J W LammersC L van Herwaarden
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Andrew H TraversBrian H Rowe
Jun 19, 2001·The Cochrane Database of Systematic Reviews·S SalpeterE Salpeter
Sep 1, 1990·DICP : the Annals of Pharmacotherapy·M T Reed, H W Kelly

Related Concepts

Adrenergic beta-Agonists
Asthma
Diastolic Blood Pressure
Pulse Rate
Hemodynamics
Dalzic
Prenalterol Hydrochloride
Respiration
Terbutalin von ct

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