Ventilatory and mouth occlusion pressure responses to hypercapnia in chronic tetraplegia

Archives of Physical Medicine and Rehabilitation
K H LinY H Wang

Abstract

To compare the ventilatory response to hypercapnia and the mouth occlusion pressure measured at 0.1 second following inspiration (P0.1) in hypercapnia between chronic tetraplegic and normal subjects. A case-control study with an uneven sample size for the study of clinical disorders. Patients were recruited from the outpatient clinic of a rehabilitation department. Seven normal men and 9 men with tetraplegia who had cervical cord injuries (C5-C8), with a mean injury duration of 9.7 yrs. Pulmonary function tests were performed during resting, whereas minute ventilation (VE) and P0.1 were measured during CO2 rebreathing. The maximal voluntary ventilation (MVV), vital capacity (VC), and maximal respiratory muscle strength in the tetraplegic subjects were significantly less than in the normal subjects. Both the ventilatory and P0.1 responses to hypercapnia were significantly reduced in tetraplegic as compared with normal subjects, but the reductions were eliminated by normalizing with maximal ventilatory performance (MVV or VC) and maximal inspiratory muscle strength (PImax), respectively. Chronic tetraplegic persons have diminished ventilatory and P0.1 responses to hypercapnia. Respiratory muscle weakness may be a primary factor c...Continue Reading

Citations

Oct 13, 2009·Lung·Ann M SpungenF D McCool
Dec 2, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Khoa TranLynne Fraser
Jul 4, 2009·The European Respiratory Journal·A RiceR F Fregosi
Jun 21, 2011·Experimental Neurology·F J GolderG S Mitchell
May 16, 2009·Respiratory Physiology & Neurobiology·Gregory J SchileroMarvin Lesser
Aug 5, 2009·Archives of Physical Medicine and Rehabilitation·Issahar Ben-DovGabriel Zeilig
Aug 26, 2014·Respiratory Physiology & Neurobiology·Philippa M WarrenWarren J Alilain
Oct 4, 2011·Experimental Neurology·Michael A LanePaul J Reier
Jul 31, 2013·Respiratory Physiology & Neurobiology·Daniel J HohMichael A Lane
Oct 12, 2013·Journal of Applied Physiology·Abdulghani SankariM Safwan Badr
Nov 22, 2001·Journal of Applied Physiology·F J GolderD C Bolser
Jan 16, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marie-Noëlle FiammaThomas Similowski

Related Concepts

Airway Resistance
Hypercapnia
Lung Volume Measurements
Oximetry, Pulse
Paralysis, Spinal, Quadriplegic
Respiratory Muscles
Respiratory Mechanics

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.