PMID: 2101582Jun 1, 1990Paper

Ventilatory control during exercise in calves with artificial hearts

Journal of Applied Physiology
A HuszczukD B Olsen

Abstract

To determine the role of cardiac reflexes in mediating exercise hyperpnea, we investigated ventilatory responses to treadmill exercise in seven calves with artificial hearts and seven controls. In both groups, the ventilatory responses were adequate for the metabolic demands of the exercise; this resulted in regulation of arterial PCO2 and pH despite the absence of cardiac output increase in the implanted group. In this group, there was a small but significant reduction of arterial PO2 by 4 +/- 3 Torr and a rise of blood lactate by 1.1 +/- 1 mmol/l. When cardiac output was experimentally increased in the implanted calves to a level commensurate with that spontaneously occurring in the control calves, ventilation was not affected. However, experimental reductions of cardiac output led to an immediate augmentation of exercise hyperpnea by 4.56 +/- 4.3 l/min and a further significant lactate increase of 1.2 +/- 1.22 mmol/l that was associated with a significant decrease in the exercise O2 consumption (0.32 +/- 0.13 l/min). These observations indicate that neither cardiac nor hemodynamic effects of increased cardiac output constitute an obligatory cause of exercise hyperpnea in the calf.

Citations

Nov 8, 2001·Experimental Physiology·P HaouziB Chalon
Oct 17, 1998·British Journal of Sports Medicine·B J Whipp, S A Ward
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·J H Mateika, J Duffin
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·P CerretelliG Ferretti
Feb 12, 1999·Scandinavian Journal of Medicine & Science in Sports·M KjaerN H Secher
Mar 16, 2002·Journal of Applied Physiology·Philippe HaouziBernard Chalon
Sep 1, 1994·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·S A Ward
Jan 1, 1995·Respiration Physiology·P HaouziB J Whipp

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