PMID: 9543263May 16, 1998Paper

Ventilatory control in patients with sleep apnoea and left ventricular dysfunction: comparison of obstructive and central sleep apnoea

The European Respiratory Journal
I WilcoxC E Sullivan

Abstract

Sleep apnoea is common in patients with heart failure. While most patients have central sleep apnoea (CSA), a minority have obstructive sleep apnoea (OSA). The pathophysiology of CSA is not well understood. We hypothesized that central chemosensitivity would be an important pathophysiological factor in patients with CSA, and not in OSA. The aim of this study was to compare ventilatory responses between patients with CSA and those with OSA. Acute ventilatory responses to eucapnic hypoxia and hyperoxic hypercapnia were measured during wakefulness in 34 patients (33 males and one female, aged 59+/-8 yrs (mean+/-SD)), with stable medically-treated left ventricular dysfunction (LVD) and sleep apnoea (18 OSA and 16 CSA). Patients with CSA had a decreased awake end-tidal carbon dioxide tension (4.1+/-0.5 kPa), increased ventilatory response to carbon dioxide (0.65+/-0.43 L.min.(-1).kPa PCO2(-1)), and eucapnic hypoxic responses in the normal range (0.6+/-0.4 L.min(-1)/% fall in arterial oxygen saturation (Sa,O2)). In contrast, patients with OSA had normal end-tidal carbon dioxide tension (4.9+/-0.5 kPa), and normal ventilatory responses to hypercapnia (0.29+/-0.16 L.min(-1).kPa PCO2(-1)) and hypoxia (0.5+/-0.5 L-min(-1)/% fall in Sa,O2...Continue Reading

Citations

Sep 14, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Olaf OldenburgDieter Horstkotte
Nov 16, 2011·Pflügers Archiv : European journal of physiology·Richard S T LeungDaniel Stevens
Jun 24, 2004·Sleep & Breathing = Schlaf & Atmung·Masaaki SuzukiToshimitsu Kobayashi
May 14, 2003·Journal of the American College of Cardiology·Jo-Dee L LattimoreIan Wilcox
Jul 11, 2003·Respiratory Physiology & Neurobiology·Paola A Lanfranchi, Virend K Somers
Sep 25, 1999·The New England Journal of Medicine·S Javaheri
Feb 5, 2000·The New England Journal of Medicine·I WilcoxC E Sullivan
Jan 11, 2001·The New England Journal of Medicine·P J Hanly, A Pierratos
Feb 26, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Keith R Burgess, Norbert Berend
Jan 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Keith R BurgessAllan Hahn
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·P SolinM T Naughton
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·R S Leung, T D Bradley
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·H TeschlerM Berthon-Jones
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Ailiang XieJerome A Dempsey
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Hideaki NakayamaJerome A Dempsey
May 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Gary G Kay, Neil Feldman
Feb 24, 2001·Aging : Clinical and Experimental Research·J P JanssensJ P Michel
Jul 12, 2008·Heart Failure Reviews·Samuel L KrachmanWissam Chatila
Oct 27, 2012·Neurologic Clinics·Octavian C Ioachimescu, Nancy A Collop
Jun 15, 2010·Respiratory Physiology & Neurobiology·Limei ChengMichael C K Khoo
Dec 27, 2008·Progress in Cardiovascular Diseases·Richard S T Leung
Jun 26, 2008·Respiratory Physiology & Neurobiology·Andrew WellmanDavid P White
Aug 17, 2006·Journal of Sleep Research·R TkacovaT D Bradley
Mar 7, 2002·IEEE Transactions on Bio-medical Engineering·Musa H AsyaliMichael C K Khoo
Jun 20, 2006·Respiratory Physiology & Neurobiology·Zbigniew L ToporJohn E Remmers
Jul 3, 2017·Journal of the American Heart Association·Patricia TungSusan Redline
Jul 18, 2019·Current Opinion in Pulmonary Medicine·Winfried Randerath, Simon Herkenrath
Nov 30, 1999·Annals of Internal Medicine·D D Sin, T D Bradley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory and Critical Care Medicine
G Lorenzi-FilhoT Douglas Bradley
© 2022 Meta ULC. All rights reserved