PMID: 9547439Apr 21, 1998Paper

Ventilatory drive during exercise in congestive heart failure

Journal of Cardiac Failure
G A MacGowanS Murali

Abstract

Continuous increases in the ventilatory equivalent for carbon dioxide (the ratio of minute ventilation to carbon dioxide production, an index of ventilatory drive) during exercise in patients with congestive heart failure would suggest that factors other than carbon dioxide excessively stimulate ventilation during exercise, and may be an important factor in exercise-related dyspnea and fatigue in these patients. Eighty-five patients with congestive heart failure and 17 normal control subjects underwent symptom-limited exercise testing with gas-exchange analysis. Patients were divided into four functional classes (A-D, Weber's classification) based on peak exercise oxygen consumption. In all heart failure patient groups and in control subjects the ventilatory equivalent for carbon dioxide decreased (P < .005, class D; P < .0001, all other groups) from rest to anaerobic threshold. Three isolated patients showed a continuous increase in ventilatory drive during exercise (mean peak oxygen consumption 13.7 mL/kg/min). In the lowest functional class (D) the ventilatory equivalent for carbon dioxide was greater than in all other groups at rest, at anaerobic threshold, and at peak exercise (P < .01). In all heart failure groups and in ...Continue Reading

Citations

Nov 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G A MacGowanS Murali
Jul 9, 2008·International Journal of Food Sciences and Nutrition·Zehra Güler, Hasan Sanal

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