Oct 1, 1985

Ventilatory effects of atenolol and bevantolol in asthma

Clinical Pharmacology and Therapeutics
J W LammersC L van Herwaarden

Abstract

The cardioequipotency of 400 mg bevantolol and 100 mg atenolol was determined by measuring the exercise heart rate in healthy subjects. The beta-blockers were then used in these doses to investigate their ventilatory effects in patients with asthma. The effects of both drugs on forced expiratory flow parameters for large and small airways were assessed at rest and during and after exercise. A dose-response curve was then plotted after inhalation of the beta 2-adrenoceptor agonist terbutaline. Bevantolol significantly decreased the forced expiratory volume in 1 second (FEV1) and the peak expiratory flow rate (PEFR) at rest, while there was no such change with placebo or atenolol. Both beta-blockers decreased the maximal expiratory flow rates at 50% of forced vital capacity (MEF50) and after expiration of 75% of the forced vital capacity (MEF25) at rest; the decrease was larger after bevantolol than after atenolol. During atenolol there was a decrease in FEV1 and in PEFR (P less than 0.01) 15 minutes after exercise in comparison with preexercise values. There was no significant difference between pre- and postexercise values of MEF50 and MEF25 during atenolol dosing. After bevantolol there was only a small change in PEFR after ex...Continue Reading

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Mentioned in this Paper

Expiration, Function
Peak Expiratory Flow Rate Measurement
Diastolic Blood Pressure
Respiratory Muscles
Vital Capacity Test
Propanolamines
Pharmacologic Substance
Drug Evaluation
Asthma
Adrenergic Receptor

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