PMID: 1110233Jan 1, 1975

Ventilatory effects of hypoxia and their dependence on PCO2

Journal of Applied Physiology
A S Rebuck, W E Woodley

Abstract

In 11 healthy subjects the effect of progressive hypoxia on pulmonary ventilation at various alveolar carbon dioxide pressures was studied. A rebreathing technique was used to produce hypoxia, CO2 was held constant and oxygen saturation was taken as the independent variable. We found a linear relationship between ventilation and falls in oxygen saturation when Pco2 was held at the resting mixed venous, end-tidal, or any intermediate level. Within this range of Pco2, a family of ventilation-So2 response curves was obtained for each subject. The effect of altering the isocapnic level was to change the slope and position of the ventilation-So2 response curve, the amount by which the slope changed being related to the slope for that subject at their mixed venous Pco2.

Citations

Jul 28, 1977·The New England Journal of Medicine·A J BergerJ W Severinghaus
Dec 1, 1979·British Heart Journal·A S SlutskyA S Rebuck
Sep 1, 1980·Canadian Anaesthetists' Society Journal·A S SlutskyA S Rebuck
Sep 22, 1998·Anesthesiology·C R CartwrightD S Ward
Aug 19, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Philip G D Matthews
Oct 1, 1995·Acta Anaesthesiologica Scandinavica·A Sollevi, S G Lindahl
Jan 1, 1979·Annals of Biomedical Engineering·N IkedaT Sato
Dec 9, 2003·Journal of Applied Physiology·Neil S Cherniack
Dec 10, 2002·American Journal of Respiratory and Critical Care Medicine·Ola HafströmHåkan W Sundell
Jan 1, 1992·Annals of Biomedical Engineering·D S WardC B Mann
Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Stephen CorneMagdy Younes
Jun 26, 2020·Journal of Applied Physiology·Hayden W HessBlair D Johnson
Jun 1, 1979·Journal of Neurosurgery·E A Frost

Related Concepts

Anoxemia
Carbon Dioxide
Dioxygen
Pulmonary Alveolar Structure
Respiration

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.