Ventilatory instability during sleep onset in individuals with high peripheral chemosensitivity

Journal of Applied Physiology
J DunaiJohn Trinder

Abstract

Previous work has shown that the magnitude of state-related ventilatory fluctuations is amplified over the sleep-onset period and that this amplification is partly due to peripheral chemoreceptor activity, because it is reduced by hyperoxia (J. Dunai, M. Wilkinson, and J. Trinder. J. Appl. Physiol. 81: 2235-2243, 1996). These data also indicated considerable intersubject variability in the magnitude of amplification. A possible source of this variability is individual differences in peripheral chemoreceptor drive (PCD). We tested this hypothesis by measuring state-related ventilatory fluctuations throughout sleep onset under normoxic and hyperoxic conditions in subjects with high and low PCD. Results demonstrated that high-PCD subjects experienced significantly greater amplification of state-related ventilatory fluctuations than did low-PCD subjects. In addition, hyperoxia significantly reduced the amplification effect in high-PCD subjects but had little effect in low-PCD subjects. These results indicate that individuals with high PCD are likely to experience greater sleep-related ventilatory instability and suggest that peripheral chemoreceptor activity can contribute to sleep-disordered breathing.

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Citations

Aug 21, 2015·Physiological Reports·Amy T BascomM S Badr
Jan 20, 2016·Sleep & Breathing = Schlaf & Atmung·Adam B Hernandez, Susheel P Patil
Jun 16, 2017·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Adelita TinocoMichele M Pelter
Jan 13, 2018·American Journal of Respiratory and Critical Care Medicine·Scott A SandsAndrew Wellman
Sep 2, 2008·Heart Failure Reviews·Safwan Badr
Feb 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ying-Jie PengNanduri R Prabhakar
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jayasri NanduriNanduri R Prabhakar
Jan 8, 2020·BMJ Open Respiratory Research·Frances ChungOp-Safe Investigators
Jul 19, 2005·Journal of Applied Physiology·Stuart ThomsonStephen J Semple

Related Concepts

Chemoreceptor Cells
Electrophysiology (Science)
Hyperventilation
Dioxygen
Respiration
Ventilator - Respiratory Equipment
Expiratory Airflow
Skin
Sleep Stages
Hyperoxia

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