PMID: 8594021Nov 1, 1995Paper

Ventilatory response to consecutive short hypercapnic challenges in children with obstructive sleep apnea

Journal of Applied Physiology
D GozalT G Keens

Abstract

In healthy adults, a ventilatory pattern characterized by progressively increased tidal volume (VT), and decreased respiratory rate (RR) accompany repeated short hypercapnic ventilatory challenges, while minute ventilation (VE) remains constant. We hypothesized that the peculiar ventilatory pattern seen in adults would be blunted in children with obstructive sleep apnea syndrome (OSAS) who undergo comparable intermittent or chronic alveolar PCO2 elevation. We measured ventilatory responses to five challenges of 2-min duration (C1-C5) with 5% CO2 in O2, separated by 5-min room-air breathing intervals (R1-R4), in nine children with OSAS and in eight age-, sex-, and body mass index-matched controls. In all children, CO2 significantly increased VE when compared with baseline conditions (22.3 +/- 2.2 vs. 9.5 +/- 0.9 (SE) l/min; P < 0.001). In control subjects, progressive VT increases from 0.67 +/- 0.10 liter in C1 to 0.92 +/- 0.13 liter in C5 occurred (P < 0.01), whereas RR decreased from 33.9 +/- 5.1 breaths/min in C1 to 27.8 +/- 3.7 breaths/min in C5 (P < 0.02), resulting in VE increases across CO2 challenges (22.3 +/- 4.9 l/min in C1 vs. 25.1 +/- 5.0 l/min in C5; P < 0.005). The RR decrease was primarily related to progressive p...Continue Reading

Citations

Feb 22, 2001·Journal of Applied Physiology·K A Waters, K D Tinworth
Aug 13, 1999·Journal of Applied Physiology·C L MarcusA Schwartz
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·C L Marcus
Jun 11, 1998·Journal of Applied Physiology·C L MarcusO Bamford
Jun 9, 2004·Treatments in Respiratory Medicine·Thomas Erler, Ekkehart Paditz
Oct 31, 2009·Journal of Applied Physiology·Raanan Arens, Hiren Muzumdar
Apr 19, 2002·Journal of Applied Physiology·Karen A WatersSally Wharton
May 1, 2004·BMC Pulmonary Medicine·Ralph F FregosiElena Antonio
Aug 29, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Reginald F Baugh

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