PMID: 8941519Nov 1, 1996Paper

Ventilatory response to exercise in diabetic subjects with autonomic neuropathy

Journal of Applied Physiology
C TantucciC A Sorbini

Abstract

We have used diabetic autonomic neuropathy as a model of chronic pulmonary denervation to study the ventilatory response to incremental exercise in 20 diabetic subjects, 10 with (Dan+) and 10 without (Dan-) autonomic dysfunction, and in 10 normal control subjects. Although both Dan+ and Dan- subjects achieved lower O2 consumption and CO2 production (VCO2) than control subjects at peak of exercise, they attained similar values of either minute ventilation (VE) or adjusted ventilation (VE/maximal voluntary ventilation). The increment of respiratory rate with increasing adjusted ventilation was much higher in Dan+ than in Dan- and control subjects (P < 0.05). The slope of the linear VE/VCO2 relationship was 0.032 +/- 0.002, 0.027 +/- 0.001 (P < 0.05), and 0.025 +/- 0.001 (P < 0.001) ml/min in Dan+, Dan-, and control subjects, respectively. Both neuromuscular and ventilatory outputs in relation to increasing VCO2 were progressively higher in Dan+ than in Dan- and control subjects. At peak of exercise, end-tidal PCO2 was much lower in Dan+ (35.9 +/- 1.6 Torr) than in Dan- (42.1 +/- 1.7 Torr; P < 0.02) and control (42.1 +/- 0.9 Torr; P < 0.005) subjects. We conclude that pulmonary autonomic denervation affects ventilatory response to...Continue Reading

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Citations

Jun 10, 2008·Chronic Respiratory Disease·A KaparianosK Spiropoulos
Sep 25, 2017·Endocrine Reviews·Albert LecubeFerran Barbé
Dec 22, 2010·European Journal of Medical Research·Kurt RascheM Pokorski
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Oct 3, 2006·Diabetes/metabolism Research and Reviews·Raffaele Antonelli IncalziGiovanni Ghirlanda
Apr 25, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C O FranciscoA M O Leal
Feb 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Masaharu KataokaSatoshi Ogawa

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