PMID: 8946574Oct 1, 1996Paper

Ventilatory response to hypoxia in rats: gender differences

Respiration Physiology
Jacopo P Mortola, C Saiki

Abstract

The ventilatory response to hypoxia of adult conscious rats, measured during sleep as change in ventilation-oxygen consumption ratio (VE/VO2) while breathing 10% O2 for 15-30 min, was found to be approximately 23% larger in females (female) than in males (male, p < 0.001). Also arterial PCO2 during hypoxia decreased more in female. The gender difference occurred at all metabolic levels, and was not related to normoxic VE/VO2 or the hypometabolic response to hypoxia; it was solely due to greater hyperpnea in female. With hypoxia, changes in blood pressure, heart rate and body temperature were similar between male and female; hence, gender differences in baro- or thermal-stimuli were not a contributing factor. Hematocrit, hemoglobin, lung, heart and diaphragm mass/body weight were also similar, whereas respiratory system compliance was higher, and resistance lower, in female. Ovariectomy did not change the female response. In prepubertal rats the VE/VO2 hypoxic response was also larger in female (approximately 12%, p < 0.05). After prolonged (approximately 4 months) hypoxia, the gender difference in the response to acute hypoxia was no longer statistically significant. In conclusion, conscious adult female rats have a higher vent...Continue Reading

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Citations

Jul 11, 2002·Respiratory Physiology & Neurobiology·Jacopo P Mortola, Erin L Seifert
Jul 11, 2003·Respiratory Physiology & Neurobiology·Mary BehanGordon S Mitchell
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Christian GestreauJacques Barhanin
Jun 9, 2000·Annual Review of Physiology·J P Mortola, P B Frappell
Mar 7, 2009·Journal of Applied Physiology·J M WenningerM Behan
Feb 28, 2009·Journal of Applied Physiology·Grégory M BlainJerome A Dempsey
Nov 26, 2009·Proceedings of the American Thoracic Society·Jeffrey W Card, Darryl C Zeldin
Dec 18, 2007·High Altitude Medicine & Biology·Edgar CristanchoDieter Böning
Aug 11, 2000·Respiration Physiology·K FenelonJ P Mortola
Mar 24, 2016·High Altitude Medicine & Biology·Christopher John BoosDavid Richard Woods
Nov 25, 2003·The Journal of Physiology·Sophie-Emmanuelle GenestRichard Kinkead
Nov 28, 2012·Respiratory Physiology & Neurobiology·Lisa A PalmerStephen J Lewis
Aug 21, 2007·Respiratory Physiology & Neurobiology·Lorna G MooreEnrique Vargas
Oct 6, 2005·Respiratory Physiology & Neurobiology·J Soliz, V Joseph
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Aug 25, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Luciane H GargaglioniLuis Gustavo A Patrone

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