PMID: 2117008Jun 1, 1990Paper

Ventilatory responses to inspiratory threshold loading in humans

Journal of Applied Physiology
J YanosK Greenawalt

Abstract

Normal alveolar ventilation tends to be maintained during external mechanical loading. The precise manner by which this occurs is unclear but may involve intrinsic mechanisms related to the muscular pump, neural influences, and chemoreceptor control. Recent observations suggest that submaximal threshold loads may result in hyperventilation. In this study we explicitly examined the respiratory effects of sustained threshold loading in normal subjects. We found that sustained threshold loading resulted in hyperventilation associated with high P100's (mouth pressure 100 ms after the start of an occluded breath) and increased tidal volumes but with little effect on duty cycle or respiratory rate. In addition, this increased respiratory motor output was sustained for 30-60 s after the load was removed. At very high threshold loads, hyperventilation failed to occur, despite increased P100's. We conclude that threshold loading results in increased respiratory motor output and hyperventilation, a response that is different from that observed with either resistive or elastic loads, and that the failure to hyperventilate at the higher loads may be the result of mechanical limitation.

Citations

Jun 8, 2007·Behavior Research Methods·Andreas von Leupoldt, Bernhard Dahme
Mar 6, 1999·Journal of Applied Physiology·S Yan, J H Bates
Jan 24, 2012·Journal of Applied Physiology·Guillaume BouvierCapucine Morélot-Panzini
Feb 11, 2015·Journal of Applied Physiology·Elise MorawiecThomas Similowski
Apr 18, 2020·The European Respiratory Journal·David LawiDan Adler
Jan 20, 2007·Journal of Applied Physiology·Emma Z RossAlison K McConnell
Jan 30, 2010·Journal of Applied Physiology·Lysandre TremoureuxThomas Similowski

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