Ventral Hippocampal Afferents to Nucleus Accumbens Encode Both Latent Vulnerability and Stress-Induced Susceptibility.

Biological Psychiatry
Jessie MuirRosemary C Bagot

Abstract

Stress is a major risk factor for depression, but not everyone responds to stress in the same way. Identifying why certain individuals are more susceptible is essential for targeted treatment and prevention. In rodents, nucleus accumbens (NAc) afferents from the ventral hippocampus (vHIP) are implicated in stress-induced susceptibility, but little is known about how this pathway might encode future vulnerability or specific behavioral phenotypes. We used fiber photometry to record in vivo activity in vHIP-NAc afferents during tests of depressive- and anxiety-like behavior in male and female mice, both before and after a sex-specific chronic variable stress protocol, to probe relationships between prestress neural activity and behavior and potential predictors of poststress behavioral adaptation. Furthermore, we examined chronic variable stress-induced alterations in vHIP-NAc activity in vivo and used ex vivo slice electrophysiology to identify the mechanism of this change. We identified behavioral specificity of the vHIP-NAc pathway to anxiety-like and social interaction behavior. We also showed that this activity is broadly predictive of stress-induced susceptibility in both sexes, while prestress behavior is predictive only o...Continue Reading

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Citations

Oct 27, 2020·Frontiers in Neuroscience·Hanista PremachandranMaithe Arruda-Carvalho
Feb 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Evelyn Ordoñes SanchezDebra A Bangasser
May 10, 2021·Biological Psychiatry·Joëlle Lopez, Rosemary C Bagot
Jun 12, 2021·Nature Communications·Daniel C LowesAlexander Z Harris
Jul 28, 2021·Methods : a Companion to Methods in Enzymology·Christopher K LaffertyJonathan P Britt

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