PMID: 2118496Jul 1, 1990Paper

Ventral medulla sites of muscarinic receptor subtypes involved in cardiorespiratory control

Journal of Applied Physiology
E E Nattie, A H Li

Abstract

Bilateral 10-nl injections of the muscarinic (M1) receptor antagonist pirenzepine (PZ) and the M3-antagonist 4-diphenylacetoxy-N-methylpiperidine (DAMP) just below the surface of the rostral ventrolateral medulla (VLM) in anesthetized, paralyzed, vagotomized, glomectomized, servo-ventilated cats decreased base-line phrenic activity and CO2 sensitivity but not blood pressure. Unilateral 10-nl injections of PZ, DAMP, or the M2-antagonist AFDX-116 resulted in the following. AFDX-116 greater than PZ greater than DAMP decreased blood pressure. DAMP greater than PZ greater than AFDX-116 decreased base-line phrenic activity and the CO2 response slope. Many injections had no effect, and some affected only one variable. The injection sites were within 700 microns of the VLM surface extending from the caudal aspect of the superior olive through a region ventromedial to the facial nucleus to the rostral aspect of the inferior olive. In a small number of experiments the response to carotid sinus nerve stimulation was affected by some injections of each antagonist. In the rostral VLM cardiovascular regulation involves M2-receptors, whereas respiratory regulation involves predominantly the M3-subtype. Neurons with these receptors appear to b...Continue Reading

Citations

Sep 18, 1997·Journal of Applied Physiology·C L CreamE E Nattie
Dec 31, 1997·The Annals of Otology, Rhinology, and Laryngology·B E RichardsonG S Goding
Jun 2, 2001·Journal of Neurophysiology·X M Shao, J L Feldman
Nov 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·J LaiJ L Feldman
Nov 3, 2011·Journal of Receptor and Signal Transduction Research·Hidetoshi AsaiOsamu Doi
Mar 8, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·T R AnjuC S Paulose
Jun 14, 2005·American Journal of Physiology. Heart and Circulatory Physiology·James R PadleyAnn K Goodchild
Jun 6, 2009·Acta Pharmacologica Sinica·Xuesi M Shao, Jack L Feldman
Nov 4, 2016·The Journal of Physiology·Rozlyn C T BoutinSilvia Pagliardini
Sep 8, 2019·The Journal of Pharmacology and Experimental Therapeutics·Randy Torralva, Aaron Janowsky
Sep 27, 2003·The European Journal of Neuroscience·Fabrice ChatonnetArthur S Foutz
Mar 29, 2002·Molecular Psychiatry·Marco Battaglia
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Claudio CoddouJaime Eugenín
Jan 29, 2016·Developmental Neurobiology·Lila B WollmanRalph F Fregosi
Sep 1, 2000·Respiration Physiology·M D Burton, H Kazemi
Dec 21, 1993·European Journal of Pharmacology·U OzkutluS Oktay
May 1, 1994·Respiration Physiology·E E NattieQ Huang
Jul 7, 2021·Respiratory Physiology & Neurobiology·Shino KatsukiMasahiko Izumizaki
Nov 4, 2008·Respiratory Physiology & Neurobiology·Eliane BoudinotArthur S Foutz

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