Ventricular actuation improves systolic and diastolic myocardial function in the small failing heart

The Annals of Thoracic Surgery
M P AnstadtPeer M Portner

Abstract

Direct mechanical ventricular actuation (DMVA) provides non-blood contacting augmentation of ventricular function. The device has promise for supporting the pediatric heart. The purpose of this study was to assess DMVA's effect in a small animal model of heart failure. Anesthetized rabbits (n = 6) underwent sternotomy and were instrumented for hemodynamic monitoring. A 10-MHz ultrasound probe was used for transesophageal echocardiography imaging. Heart failure (cardiac output <50% baseline) was induced with esmolol. Phenylephrine was titrated to maintain baseline mean arterial pressure. Transesophageal echocardiography imaging was acquired at baseline, heart failure, and subsequent DMVA support for 2 hours. Image analysis was used to derive ejection fraction, cardiac output, and stroke work as measures of left ventricular function. Speckle tracking software was used to derive myocardial strain rates as load-independent measures of left ventricular myocardial function. Mean ejection fraction was significantly increased during DMVA support (0.585 +/- 0.035) versus failure (0.215 +/- 0.014; p < 0.001). Peak global left ventricular systolic and diastolic strain rates (1/second) were significantly increased during DMVA (-2.85 +/- 0....Continue Reading

References

Apr 1, 1992·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·M P AnstadtJ E Lowe
Feb 1, 1991·Resuscitation·M P AnstadtJ E Lowe
Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Jul 1, 1995·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·R A Perez-TamayoJ E Lowe
Feb 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·B W DuncanJ M Wilson
Jul 10, 1999·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·C J BruceJ B Seward
Feb 16, 2002·The Annals of Thoracic Surgery·Mark P AnstadtYukihiko Nosé
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Frank WeidemannFrank E Rademakers
Oct 26, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mehmet C OzDaniel Burkhoff
Jun 7, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yifei HuangStephen N Hunyor
Jun 25, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mario C DengRobert L Kormos
Sep 1, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Gregory GilmanMarek Belohlavek
Dec 21, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David RosenthalJeffrey Towbin
Mar 31, 2005·The Annals of Thoracic Surgery·Eric Monnet, Juan Carlos Chachques
May 17, 2006·Circulation·Elizabeth D BlumeUNKNOWN Pediatric Heart Transplant Study Investigators
Feb 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Zoran B PopovićMarc S Penn
Aug 2, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·George Thomas
May 30, 2009·Journal of Cardiac Failure·Alan J BankUNKNOWN PROMISE-CRT Investigators

❮ Previous
Next ❯

Citations

Jul 4, 2012·The Journal of Thoracic and Cardiovascular Surgery·Michael H KwonFrederick Y Chen
Jul 29, 2010·Journal of Thrombosis and Haemostasis : JTH·S SchulmanS J Wilson
Sep 23, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Patrick I McConnellBrad L Youngblood
Mar 28, 2020·JACC. Basic to Translational Science·Mossab Y SaeedNikolay V Vasilyev

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Mehmet C OzDaniel Burkhoff
The Journal of Thoracic and Cardiovascular Surgery
Charles T KlodellChristof Huth
© 2022 Meta ULC. All rights reserved