Ventricular Arrhythmia in Septal and Apical Hypertrophic Cardiomyopathy: The French-Canadian Experience

Frontiers in Cardiovascular Medicine
Christian SteinbergJean Champagne

Abstract

Background: Apical hypertrophic cardiomyopathy (aHCM) is thought to have a more benign clinical course compared to septal HCM (sHCM), but most data have been derived from Asian cohorts. Comparative data on clinical outcome in Caucasian aHCM cohorts are scarce, and the results are conflicting. The aim of this study was to estimate the prevalence and outcome of aHCM in French-Canadians of Caucasian descent. Methods and results: We conducted a retrospective, single-center cohort study. The primary endpoint was a composite of documented sustained ventricular arrhythmia (VA), appropriate ICD therapy, arrhythmogenic syncope, cardiac arrest, or all-cause mortality. A total of 301 HCM patients (65% males) were enrolled including 80/301 (27%) with aHCM and 221/301 (73%) with sHCM. Maximal wall thickness was similar in both groups. Left ventricular apical aneurysm was significantly more common in aHCM (10 vs. 0.5%; p < 0.001). The proportion of patients with myocardial fibrosis ≥ 15% of the left ventricular mass was similar between aHCM and sHCM (21 vs. 24%; p = 0.68). Secondary prevention ICDs were more often implanted in aHCM patients (16 vs. 7%; p = 0.02). The primary endpoint occurred in 26% of aHCM and 10.4% of sHCM patients (p = 0....Continue Reading

References

Jan 1, 1990·Journal of the American College of Cardiology·J G WebbE D Wigle
Feb 19, 2002·Journal of the American College of Cardiology·Maria J ErikssonHarry Rakowski
Jul 24, 2003·Journal of the American College of Cardiology·Kinya MatsubaraMasao Nakagawa
Nov 12, 2003·The American Journal of Cardiology·Hiroaki KitaokaBarry J Maron
Sep 7, 2005·Clinical Genetics·A-M LabergeG A Mitchell
Oct 20, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Toru KuboYoshinori L Doi
Jun 2, 2010·Journal of the American College of Cardiology·UNKNOWN American College of Cardiology Foundation Task Force on Expert Consensus DocumentsPamela K Woodard
Apr 26, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehUNKNOWN Society of Cardiovascular Computed Tomography
Jul 31, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Kyung-Hee KimDae-Won Sohn
Nov 8, 2012·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-RIT Trial Investigators
Apr 2, 2013·The American Journal of Cardiology·Kyle W KlarichSteve R Ommen
Aug 9, 2013·International Heart Journal·Sung-Hwan KimYou-Ho Kim
Oct 16, 2013·European Heart Journal·Constantinos O'MahonyUNKNOWN Hypertrophic Cardiomyopathy Outcomes Investigators
Oct 17, 2013·European Journal of Human Genetics : EJHG·Héloïse GauvinMarie-Hélène Roy-Gagnon
Dec 17, 2014·Congenital Heart Disease·Eric C ToweMichael J Ackerman
Mar 6, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sue RichardsUNKNOWN ACMG Laboratory Quality Assurance Committee
May 9, 2015·Journal of the American College of Cardiology·Barry J MaronMartin S Maron
Jul 25, 2015·Journal of the American College of Cardiology·Peter W MacfarlaneGan-Xin Yan
Nov 27, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bruce L WilkoffShu Zhang
Jul 5, 2016·Human Genetics·Cécile Low-KamGuillaume Lettre
Aug 16, 2016·Cardiovascular Ultrasound·Vito Maurizio ParatoUNKNOWN Italian Chapter of ISCU
Aug 16, 2016·International Journal of Cardiology·M Fuad JanA Jamil Tajik
Jan 25, 2017·Arrhythmia & Electrophysiology Review·Ethan J Rowin, Martin S Maron
Feb 18, 2017·Journal of the American College of Cardiology·Ethan J RowinMartin S Maron
Jul 30, 2017·The Canadian Journal of Cardiology·François PhilipponMatthew Bennett

❮ Previous
Next ❯

Software Mentioned

Stata
CVI42

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.