Ventricular arrhythmias are related to the presence of autoantibodies with adrenergic activity in chronic chagasic patients with preserved left ventricular function

Journal of Cardiac Failure
Leonardo MacielEmiliano Medei

Abstract

The presence of G-type immunoglobulins with functional activity was previously demonstrated in chronic chagasic patients (CChP) with heart failure. Here we evaluated the profile and the arrhythmogenic effects of sera from CChP with preserved ventricular function. Electrocardiography (ECG), Holter monitoring, exercise testing, and left ventricular ejection fraction of 40 CChP were measured. Serum from each patient was characterized in isolated rabbit hearts where ECG parameters were analyzed. From the total sera of the 40 CChP tested in rabbit hearts, 42.5% activated β-adrenergic receptors (Ab-β), 5% activated muscarinic receptors (Ab-M), and 30% activated both muscarinic and β-receptors (Ab-Mβ). In addition, 22.5% of the sera were not reactive (Ab-NR). Ab-β patients presented more cases of arrhythmias in exercise testing (P < .001). In Holter, ventricular arrhythmias appeared more than twice as often in the Ab-β group than in the Ab-NR group and in numbers similar to the Ab-Mβ group (Ab-NR: 2; Ab-β: 5; Ab-Mβ: 3). Arrhythmias were induced by Ab-Mβ in isolated rabbit hearts. Sera from patients with Ab-Mβ, who had longer PR intervals, were able to reversibly prolong PR when perfused in isolated rabbit heart (r² = 0.74; P = .02). H...Continue Reading

References

Mar 1, 1982·Pacing and Clinical Electrophysiology : PACE·P A ChialeM B Rosenbaum
Jun 10, 2000·Memórias do Instituto Oswaldo Cruz·V Macêdo
Apr 25, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P C CostaM O Masuda
Jan 7, 2003·American Heart Journal·Sara PartingtonSung Chun
May 13, 2006·Pacing and Clinical Electrophysiology : PACE·Augusto Cardinalli-NetoReinaldo B Bestetti
Aug 4, 2006·International Journal of Cardiology·Emiliano MedeiAntonio C Campos de Carvalho
Oct 5, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bum-Rak ChoiGuy Salama
Mar 7, 2007·Circulation·Jose Antonio Marin-NetoMarcus V Simões
Jun 8, 2007·Journal of Cardiovascular Electrophysiology·Jane CaldwellStuart M Cobbe
Jun 3, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Emiliano Horacio MedeiAntonio C Campos de Carvalho
Apr 2, 2009·International Journal of Cardiology·José Geraldo Ferreira GonçalvesDalmo Correia
Jun 15, 2010·Pflügers Archiv : European journal of physiology·Michael C Sanguinetti

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Citations

Apr 20, 2018·PLoS Pathogens·Claudia N PaivaMarcelo T Bozza
May 8, 2020·Trends in Cardiovascular Medicine·Cynthia YeungAdrian Baranchuk

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