Ventricular arrhythmias with superior axis originating from the left ventricular septum: electrocardiographic characteristics predicting successful ablation and insights into their mechanism-observations from a small series of patients

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Shigeki KusaY Iesaka

Abstract

This study aimed to evaluate the electrocardiographic characteristics and predictors of successful ablation for ventricular arrhythmias (VAs) with superior axis originating in the ventricular septum. This study included 385 consecutive patients with VAs undergoing radiofrequency ablation (RFA). Of these, 14 patients (3.7%) were identified who had VAs with superior axis that were mapped to and ablated at the left ventricular (LV) septum. These patients were classified into two groups, successful (n = 9, Success-RFA) and failed (n = 5, Fail-RFA) ablation. The QRS duration of the VAs was longer in the Success-RFA than the Fail-RFA [median (25%, 75% quartile), 140 (134, 149) vs. 128 (116, 132) ms; P = 0.007]. In the Success-RFA, the QRS morphology in lead V1 exhibited qR or rSR (r < 0.2 mV) pattern. In the Fail-RFA, QRS in lead V1 demonstrated an initial R-wave of ≥0.2 mV except for one patient who demonstrated a qR pattern. The initial R-wave amplitude of <0.2 mV in lead V1 identified successful ablation cases with 100% sensitivity and 80% specificity. The magnitude of the initial R-wave amplitude in lead V1 could be related to the originating site's depth within the septal tissue, which could also explain the RFA results. Four pe...Continue Reading

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