Ventricular assist device application as a bridge to pediatric heart transplantation: a single center's experience

Transplantation Proceedings
K H HsuS S Wang

Abstract

There are limited options for mechanical circulatory support to treat end-stage heart failure in pediatric patients. Although extracorporeal membrane oxygenation is commonly used in infants and children, ventricular assist devices (VAD) provide a longer duration of support with fewer complications before recovery or as a bridge to heart transplantation (HTx), as described herein. This retrospective chart review of eight patients transplanted from April 2008 to December 2011, after left ventricular assist device (LVAD) implantation due to end-stage heart failure. Their mean age was 12 years (9-15 y) and mean body weight, 48 kg (20-78). All were New York Heart Association functional class IV with mean left ventricular ejection fractions less than 15%. The six patients (75%) received HTx after a mean LVAD support duration of 43.2 days; 2 (25%) died before a suitable heart became available. Their mean duration of LVAD support was 30 days. There were 4 (50%) who experienced clinically evident thromboembolic events: 3 (37.5%) cerebrovascular with 1 mortality and 1 (12.5%) as acute limb ischemia. Transient hemodialysis was performed in 4 (50%). Bloodstream infection identified in 6 (75%) was controlled with intravenous antibiotics. Dr...Continue Reading

References

Feb 2, 2000·The Annals of Thoracic Surgery·A E IbrahimR A Jonas
Aug 15, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Y S ChenS H Chu
Apr 14, 2007·Pediatric Transplantation·Evgenij V PotapovRoland Hetzer
Feb 13, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S Chris MalaisrieBruce A Reitz
Oct 10, 2008·Circulation·Sanjiv K GandhiCharles E Canter
Mar 17, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jane CassidyAsif Hasan
Jul 9, 2010·The Annals of Thoracic Surgery·Gianluca BrancaccioRoberto M Di Donato

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Citations

Nov 28, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Roland HetzerEva Maria Delmo Walter
Jan 29, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Seth A HollanderDavid N Rosenthal
Sep 11, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Leigh Ann DiFuscoKelley D Miller
Dec 10, 2019·Pediatric Transplantation·Leigh Ann DiFuscoKathleen A Schell
Apr 1, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brady S MoffettSebastian Tume
Aug 9, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Semra ŞenMustafa Özbaran
Jul 2, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Angela LortsAntonio Amodeo

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