PMID: 11915984Mar 28, 2002Paper

Ventricular coupling of electrical and mechanical dyssynchronization in heart failure patients

Pacing and Clinical Electrophysiology : PACE
Jean-François ToussaintMichel Paillard

Abstract

We studied the relationships of electrical and mechanical synchronization in patients with heart failure (CHF) and various degree of ventricular conduction delays. Ninety-two CHF patients (60 +/- 13 years old, LVEF < 45%), NYHA II-III-IV, and 35 age-matched control subjects were studied with angioscintigraphic phase analysis. We measured ejection fractions (LVEF, RVEF) and calculated the total activation time for the left (TtLV) and right ventricle (TtRV), and the synchronization time between right and left ventricle (TRVLV), and between LV apex and base (Tab). Patients were divided into three groups according to QRS duration: group 1 < 120 ms (n = 28), group 2 < 150 ms (n = 23), group 3 > or = 150 ms (n = 41). In group 1: LVEF = 31.1 +/- 10.9%, RVEF = 30.1 +/- 12.6%, TtLV = 204 +/- 70 ms, TtRV = 183 +/- 61 ms, TRVLV = 7 +/- 33 ms, Tab = 29 +/- 23 ms. In group 2, these were: 27.8 +/- 9.1%, 27.8 +/- 8.8%, 227 +/- 95 ms, 248 +/- 137 ms, 35 +/- 42 ms*, and 39 +/- 53 ms respectively. In group 3: LVEF = 20.5 +/- 9.5%t, RVEF = 28.4 +/- 16.1%, TtLV = 304 +/- 155 mst, TtRV = 234 +/- 106 mst, TRVLV = 64 +/- 42 mst, and Tab = 67 +/- 48 ms*, all P < 0.001 versus controls *P < 0.05 versus G1, tP < or = 0.01 versus G1. A significant relatio...Continue Reading

Citations

Feb 28, 2009·Herzschrittmachertherapie & Elektrophysiologie·G Fröhlig
Aug 9, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·J William O'ConnellElias H Botvinick
Dec 19, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Claudia DinuJean-François Toussaint
Aug 9, 2003·Journal of the American College of Cardiology·Xander A A M VerbeekFrits W Prinzen
Aug 22, 2003·Pacing and Clinical Electrophysiology : PACE·Jean-François ToussaintMichel Paillard
Jun 11, 2004·Pacing and Clinical Electrophysiology : PACE·Gerd FröhligMichael Kindermann
Nov 6, 2012·Pacing and Clinical Electrophysiology : PACE·Berthold StegemannChristoph Melzer

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