Ventricular enlargement in MS: one-year change at various stages of disease

Neurology
Catherine M DaltonD H Miller

Abstract

To investigate ventricular enlargement (VE) over 1 year at three different stages of multiple sclerosis (MS). A semi-automated technique for measuring VE was applied to MRI scans in 26 patients with clinically isolated syndromes (CIS) suggestive of MS, 30 with early relapse-onset MS of 1 year duration, 41 with established relapsing remitting (RR) MS, and 23 with secondary progressive (SP) MS. VE at 1 year was seen in early MS (median increase 0.3 mL [p = 0.003]), RRMS (median increase 0.5 mL [p = 0.001]), and SPMS (median increase 1.1 mL [p = 0.001]). Allowing for age there was more VE in the SPMS group (p = 0.005). No VE was observed in the CIS only group (median decrease -0.001 mL [p = 0.829]). Significant increases in T2 and T1 hypointense lesion load volume were seen in all MS subgroups: there were no differences between the groups in T2 volume increase but there was a larger increase in T1 hypointense lesion volume in the SPMS group compared with early RRMS. Ventricular enlargement is a sensitive measure of progressive cerebral atrophy that is seen at all stages of multiple sclerosis (MS) and is more marked in secondary progressive than relapsing remitting MS.

Citations

Apr 9, 2009·Journal of Neurology·Blandine GrassiotGilles Defer
Mar 4, 2010·Journal of Neurology·Ozgür YaldizliNorman Putzki
Nov 5, 1974·Biochimica Et Biophysica Acta·K MaruyamaE Fukada
Nov 19, 2011·Epilepsia·Daren C JacksonBruce P Hermann
Apr 5, 2012·Epilepsia·Kevin DabbsBruce Hermann
Dec 23, 2015·Expert Review of Neurotherapeutics·J William L Brown, Declan T Chard
Apr 13, 2013·Multiple Sclerosis and Related Disorders·Isabela T BorgesDaniel S Reich
Dec 11, 2008·Neuroimaging Clinics of North America·Antonio GiorgioNicola De Stefano
Jun 24, 2008·Annals of Neurology·Leonora K FisnikuDavid H Miller
Apr 12, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Nicola De StefanoStephen M Smith
Nov 12, 2013·Journal of Magnetic Resonance Imaging : JMRI·Clive B BeggsRobert Zivadinov
Apr 22, 2016·Acta Neurologica Scandinavica·R SchneiderC Lukas
Sep 18, 2016·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Paolo ZamboniFrancesco Mascoli
Apr 25, 2009·Multiple Sclerosis : Clinical and Laboratory Research·A MinnebooF Barkhof
May 25, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Özlem KirazlıSafiye Çavdar
Jun 23, 2020·Brain Connectivity·Susan L BenearIngrid R Olson
Nov 6, 2015·Frontiers in Neuroscience·Seonjoo LeeDzung L Pham
Sep 26, 2020·Frontiers in Neurology·De-Cai TianXinghu Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.