PMID: 8600655Dec 1, 1995Paper

Ventricular fibrillation after administration of adenosine

Vnitr̆ní lékar̆ství
J PellaR Novotný

Abstract

In the submitted case-history the authors describe a hitherto unknown proarrhythmic effect of adenosine. Adenosine was administered on account of supraventricular tachycardia and the undesirable proarrhythmic effect was so-called "sine wave-like tachycardia" and ventricular fibrillation. Proarrhythmia was resistant to electric cardioversion and resuscitation was successful probably only after the breakdown of adenosine. The very short half-life of breakdown of this antiarrhythmic is thus useful not only for antiarrhythmic strategy but, because of the possible occurrence of rare proarrhythmias, adenosine holds a preferential position among other antiarrhythmic drugs.

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