Ventricular myocarditis coincides with atrial myocarditis in patients

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Mark P V BegienemanPaul A J Krijnen

Abstract

Atrial fibrillation (AF) is a common complication in myocarditis. Atrial inflammation has been suggested to play an important role in the pathophysiology of AF. However, little is known about the occurrence of atrial inflammation in myocarditis patients. Here, we analyzed inflammatory cell numbers in the atria of myocarditis patients without symptomatic AF. Cardiac tissue was obtained postmortem from lymphocytic myocarditis patients (n=6), catecholamine-induced myocarditis patients (n=5), and control patients without pathological evidence of heart disease (n=5). Tissue sections of left and right ventricle and left and right atrium were stained for myeloperoxidase (neutrophilic granulocytes), CD45 (lymphocytes), and CD68 (macrophages). These cells were subsequently quantified in atrial and ventricular myocardium and atrial adipose tissue. In lymphocytic myocarditis patients, a significant increase was observed for lymphocytes in the left atrial adipose tissue. In catecholamine-induced myocarditis patients, significant increases were found in the atria for all three inflammatory cell types. Infiltrating inflammatory cell numbers in the atrial myocardium correlated positively with those in the ventricles, especially in catecholami...Continue Reading

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Citations

Nov 11, 2016·Nature Reviews. Cardiology·Eduard Guasch, Lluís Mont
Aug 12, 2016·Circulation. Cardiovascular Imaging·Juerg Schwitter
Aug 30, 2019·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Darius DabirDaniel Thomas
Apr 10, 2020·Journal of Cardiovascular Translational Research·Riccardo VioDomenico Corrado
Oct 18, 2018·Journal of Arrhythmia·Svetlana Ivanovna SazonovaSergey Valentinovich Popov
Apr 4, 2021·Medicina·Paolo CompagnucciMichela Casella
Jul 11, 2021·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Linghe WuPaul A J Krijnen
Aug 4, 2021·Indian Journal of Pathology & Microbiology·Saloni Naresh ShahSanjay Theodore

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