PMID: 11934599Apr 6, 2002Paper

Ventricular remodeling after myocardial infarction and effects of ACE inhibition on hemodynamics and scar formation in SHR

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Tomasz ZdrojewskiG Ertl

Abstract

The effect of ACE inhibition after myocardial infarction (MI) on MI healing and remodeling in the presence of hypertension is not exactly known. Therefore, the effect of quinapril on scar formation, remodeling and hemodynamics was studied in spontaneously hypertensive rats (SHR). Nine weeks after moderate and large MI, left ventricular end-diastolic pressure (LVEDP) and passive pressure-volume relations were similar in 28-week-old hypertensive and normotensive rats. Chronic therapy with quinapril (6 mg/kg/day, started 30 min post-MI) reduced LVEDP and LV to body weight ratio, yet did not affect pressure-volume relations. Quinapril increased MI size and reduced the content and brightness of collagen fibers in the scar examined by polarized light microscopy. In conclusion, ventricular dilatation after MI was not accelerated in SHR, probably due to LV hypertrophy. Quinapril produced beneficial hemodynamic effects similar to that observed in the normotensive rat model. The significance and timing of ACE inhibitor-induced impairment of scar formation need further evaluation.

References

Feb 1, 1991·Clinical and Experimental Pharmacology & Physiology·C I JohnstonB Fabris
Apr 1, 1989·Clinical and Experimental Pharmacology & Physiology·B FabrisC I Johnston
Nov 1, 1988·Journal of the American College of Cardiology·S E NolanH F Weisman
Jul 1, 1985·Circulation Research·J M PfefferE Braunwald
Mar 1, 1983·The American Journal of Cardiology·E J BrownE Braunwald
Sep 1, 1982·The American Journal of Cardiology·P J FletcherE Braunwald
Jun 1, 1995·Journal of the American College of Cardiology·T H LeJemtelE H Sonnenblick
Jun 1, 1993·Circulation Research·W SchorbK M Baker
Feb 1, 1996·Journal of Molecular and Cellular Cardiology·D C LefroyP A Poole-Wilson
Jun 1, 1996·Journal of Molecular and Cellular Cardiology·C de C FrimmK T Weber
Aug 1, 1997·Journal of Molecular and Cellular Cardiology·Y SunK T Weber
Jul 4, 1998·European Journal of Pharmacology·T MoriK Kawamura
Dec 11, 1999·Journal of Molecular and Cellular Cardiology·M JacobsW Schorb

❮ Previous
Next ❯

Citations

Feb 22, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Germán E GonzálezRicardo J Gelpi
Mar 23, 2005·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Germán E GonzálezCelina Morales
Nov 2, 2007·Clinical and Experimental Pharmacology & Physiology·Luisa M G de Macedo BragaNance Beyer Nardi
Jul 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·David JeggerNikolaos Stergiopulos
Feb 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Georg Ertl, Stefan Frantz
Nov 13, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Gavin R NortonD Paul Thomas
May 12, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Germán E GonzálezCelina Morales

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Arrhythmogenic Right Ventricular Dysplasia

Arrhythmogenic right ventricular dysplasia is a congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the right ventricle wall and loss of myocardial cells. Primary injuries usually are at the free wall of the right ventricular and right atria resulting in ventricular and supraventricular arrhythmias. Discover the latest research on arrhythmogenic right ventricular dysplasia here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.