Abstract
The aim of this study was to assess ventricular repolarization wave variations during the amiodarone treatment course for patients with ventricular arrhythmias and atrial fibrillation.Sixty-nine patients with ventricular arrhythmias and 9 patients with persistent atrial fibrillation were treated with intravenous injection of a 150 mg loading dose of amiodarone, followed by 1 mg/minute for 6 hours and 0.5 mg/minute for 48 hours. After the initial 24 hours of intravenous injection, amiodarone was also administered orally at a dose of 0.2 g tid for 1 week; followed by 0.2 g bid for 1 week and 0.2 g qd for maintenance. During the procedure, the heart rate, QT, QTc, QTd, QTcd TpTe, TpTe-c, TpTe-d, TpTe/QT, and QTp were measured on days 1, 3, 7, 10, 14, 17, and 20 of amiodarone treatment.The control rate of arrhythmias was 91.0% (71/78). The heart rate dropped significantly on the 7th day after treatment initiation and reached the minimal value on day 14. The QT interval was prolonged from day 3; TpTe was prolonged from day 7 to day 14; QTp was prolonged from day 1 to day 20. The longest QT interval (441.2 ± 33.9 ms) and TpTe (95.0 ± 18.0 ms) occurred on day 14. QTc, QTd, QTcd, TpTe-c, TpTe-d, and TpTe/QT showed no significant change...Continue Reading
References
Dec 1, 1991·Circulation Research·C AntzelevitchD W Liu
Dec 12, 1997·Journal of Cardiovascular Electrophysiology·S SicouriC Antzelevitch
Apr 11, 2000·Journal of Molecular and Cellular Cardiology·P TaggartP Kallis
Jan 5, 2001·Pacing and Clinical Electrophysiology : PACE·A LubinskiG Swiatecka
May 30, 2001·Cardiovascular Research·P TaggartP Kallis
Jul 17, 2001·European Journal of Clinical Investigation·C Antzelevitch
Jul 17, 2001·European Journal of Clinical Investigation·R WolkJ Rezler
Jan 19, 2002·Journal of Cardiovascular Electrophysiology·T Emori, C Antzelevitch
Sep 16, 2003·The American Journal of Cardiology·Peter SmetanaMarek Malik
Aug 3, 2004·Journal of Electrocardiology·Norikazu WatanabeTakashi Katagiri
Sep 15, 2005·Circulation·Michiel J JanseMichael R Rosen
Dec 24, 2005·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Yunlong XiaShiwen Yuan
Jan 24, 2007·Journal of the American College of Cardiology·Ian TopilskiSami Viskin
Sep 16, 2008·Journal of Electrocardiology·Prasad GuptaGan-Xin Yan
Nov 29, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Jin Won KimYoung-Hoon Kim
Aug 1, 2009·Journal of Electrocardiology·Christian HaarmarkJørgen K Kanters
Apr 23, 2011·Journal of Electrocardiology·Peter SmetanaMarek Malik
May 20, 2011·Circulation. Arrhythmia and Electrophysiology·Ragesh PanikkathSumeet S Chugh
Oct 31, 2012·Pacing and Clinical Electrophysiology : PACE·Chirag BarbhaiyaPaul Schweitzer
Jul 11, 2014·Coronary Artery Disease·Mustafa CetinSami Ozgul