Ventricular self-defibrillation in mammals: age and drug dependence

Age and Ageing
M ManoachM Weinstock

Abstract

Ventricular fibrillation (VF) was electrically induced in cats, rabbits, guinea pigs and rats. In young animals of all species and also in old rats short transient VF (TVF) was followed by spontaneous reversion to normal sinus rhythm. Old cats, rabbits and guinea pigs had episodes of sustained VF (SVF) which did not terminate spontaneously; artificial electro-defibrillation was required. Dibenzepin converted the sustained response of old animals to a transient one. Verapamil antagonized the effect of dibenzepin in old animals and also changed the TVF in young animals to SVF. The effect of calcie age of the animal is an important factor in determining whether the fibrillatory red to an alteration in the properties of the cell membrane.

Citations

May 24, 2007·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Jason M MeunierAbhijit R Patwardhan
Jan 1, 1989·General Pharmacology·M ManoachM Erez
Oct 26, 2001·Bioorganic & Medicinal Chemistry Letters·O LevyE Keinan
Dec 1, 1993·British Heart Journal·L ReisinM Manoach
Oct 1, 1993·Journal of Basic and Clinical Physiology and Pharmacology·M ManoachM Erez
Oct 1, 1993·Journal of Basic and Clinical Physiology and Pharmacology·L FalkinK P Bøgesø
Oct 1, 1993·Journal of Basic and Clinical Physiology and Pharmacology·D VaronN V Kaverina
Sep 2, 2000·Journal of Cardiovascular Electrophysiology·I R EfimovP J Tchou
Feb 26, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Martin J BishopGernot Plank
Jan 27, 1992·Annals of the New York Academy of Sciences·M ManoachD Varon
Nov 9, 2005·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Raymond E Ideker, Jian Huang
Mar 21, 2007·Journal of Cellular and Molecular Medicine·M ManoachT Podzuweit
Jul 1, 1988·The American Journal of Cardiology·M ManoachD Varon
Dec 1, 1988·International Journal of Cardiology·M ManoachM Erez
Mar 1, 1984·International Journal of Cardiology·M Manoach
Feb 1, 1990·International Journal of Cardiology·M Manoach, M B Basat
Aug 2, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Hui-Nam PakShien-Fong Lin
Sep 6, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Yuanna ChengIgor R Efimov
Aug 3, 2001·Cardiovascular Drug Reviews·M Manoach, N Tribulova
Jan 28, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Martin J BishopEdward J Vigmond

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.