PMID: 7544544Aug 1, 1995Paper

Ventricular sensory neurons in canine dorsal root ganglia: effects of adenosine and substance P

The American Journal of Physiology
M H HuangJ A Armour

Abstract

Effects elicited by adenosine and substance P on ventricular sensory endings of 14 dorsal root ganglion afferent neurons were studied in situ in anesthetized dogs. Sensory-field application of adenosine (1 microM) increased the activity of these neurons by 179%. Application of a nonspecific adenosine antagonist to epicardial sensory fields suppressed ongoing activity in all 14 neurons by 39%. Application of an A1- or A2-adenosine-receptor antagonist suppressed activity generated by 10 of these neurons by 44 and 59%, respectively. Adenosine applied after A1- or A2-receptor blockade increased activity in 10 neurons by 131 and 145%, respectively, indicating that A1- and A2-receptor effects were not additive. Application of substance P (1 microM) to identified sensory fields increased activity in 12 of these neurons by 169%, whereas application of a substance P-receptor antagonist reduced activity generated by these neurons by 75%. Myocardial ischemia increased activity of nine neurons associated with left ventricular sensory fields by 320%, an effect that was counteracted by the nonspecific adenosine-receptor antagonist. It is concluded that A1- and A2-adenosine receptors, as well as substance P receptors, are present on ventricul...Continue Reading

Citations

Jul 24, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Andrew Armour
Nov 9, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Xiaohui DingCarole A Williams
Sep 21, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Siamak SalavatianJeffrey L Ardell
Feb 5, 2002·Journal of Neurophysiology·Hui-Lin Pan, Shao-Rui Chen
Dec 20, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Fang HuaCarole A Williams

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