PMID: 3761088Oct 1, 1986Paper

Ventricular septal thickness and cardiac function in neonates after in utero ritodrine exposure

The Journal of Pediatrics
P NuchpuckdeeH Hurt

Abstract

Cardiac septal hypertrophy occurs after in utero ritodrine exposure. To assess the effect of septal hypertrophy on cardiac function we obtained M-mode echocardiograms on day 1 of life in 41 infants exposed to ritodrine and 22 control infants matched for gestational age. Mean duration of ritodrine exposure was 16.2 +/- 13.2 days (range 1 to 49 days). Disproportionate septal hypertrophy (DSH) was defined as an interventricular septal thickness/posterior wall thickness ratio (ST/PW) of greater than 1.3. Infants exposed to ritodrine in utero had DSH and increased right systolic time intervals compared with control values (P less than 0.05). A subgroup, those infants exposed for 2 weeks or longer, had not only DSH but also an absolute increase in septal thickness compared with control infants and infants exposed to ritodrine for less than 2 weeks. ST/PW correlated well with the duration of ritodrine exposure (r = 0.96); the longer the exposure the thicker the septum. Although all echocardiographic changes lasted for less than 3 months, we have no information regarding the effect on the fetus of maternal ritodrine exposure for longer than 7 weeks. Until such information is available, cardiac evaluation is recommended in neonates expo...Continue Reading

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Citations

Apr 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M AlvarezV Goyanes
Feb 1, 1992·The Journal of Pediatrics·J P HarrisJ J Gutai
Feb 24, 2001·International Journal of Cardiology·B OcalS Karademir
Aug 1, 1994·American Journal of Obstetrics and Gynecology·D R LenselinkG L Kolesari
Nov 7, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Miguel Alvarez-SeoaneFernando Rueda-Nuñez
Mar 27, 2001·Clinics in Perinatology·A J Shillingford, S Weiner
May 10, 2002·Obstetrical & Gynecological Survey·Sheryl Rodts-Palenik, John C Morrison
Jan 1, 1993·Journal of Perinatal Medicine·A Kast, M Hermer

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