Ventricular structure and function in children with sickle cell disease using conventional and tissue Doppler echocardiography

The American Journal of Cardiology
Ahmad Charaf EddineSethuraman Swaminathan

Abstract

Conventional 2-dimensional, M-mode, and spectral Doppler echocardiographic techniques have documented abnormal ventricular function in adults with sickle cell disease (SCD), but assessments in children are conflicting. Tissue Doppler echocardiography (TDE) provides additional information about myocardial function. Two-dimensional, M-mode, tricuspid regurgitation jet velocity (TRJV) data, and tissue Doppler echocardiographically derived myocardial velocity measurements of left ventricular (LV) and right ventricular function were taken from children with SCD compared to those of similar healthy historical controls and correlated with clinical characteristics and hemoglobin levels. Compared to 55 controls, 54 children with SCD (mean age 14.2 years, range 6 to 21) had a larger left ventricle, greater LV mass, and higher LV fractional shortening; 30% had increased pulmonary artery pressure (TRJV ≥2.5 m/s). Conventional echocardiographic measurements of LV systolic function and spectral Doppler measurements of LV and right ventricular diastolic function were essentially normal, but TDE indicated that 31% of SCD children had evidence of LV diastolic dysfunction (peak early diastolic velocity of LV inflow Doppler/peak early diastolic v...Continue Reading

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Citations

Nov 29, 2012·Pediatric Cardiology·Arpan R Doshi, Linda B Pauliks
Jun 24, 2014·The International Journal of Cardiovascular Imaging·Nadjib HammoudiFrançois Lionnet
Sep 7, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Marcia M BarbosaMaria Carmo P Nunes
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