Ventricular tachyarrhythmia detection by implantable loop recording in patients with heart failure and preserved ejection fraction: the VIP-HF study.

European Journal of Heart Failure
Dirk J van VeldhuisenMichiel Rienstra

Abstract

The primary aim of the VIP-HF study was to examine the incidence of sustained ventricular tachyarrhythmias (VTs) in heart failure (HF) with mid-range (HFmrEF) or preserved ejection fraction (HFpEF). Secondary aims were to examine the incidence of non-sustained VTs, bradyarrhythmias, HF hospitalizations and mortality. This was an investigator-initiated, prospective, multicentre, observational study of patients with HF and left ventricular ejection fraction (LVEF) >40%. Patients underwent extensive phenotyping, after which an implantable loop recorder was implanted. We enrolled 113 of the planned 250 patients [mean age 73 ± 8 years, 51% women, New York Heart Association class II/III 54%/46%, median N-terminal pro B-type natriuretic peptide 1367 (710-2452) pg/mL and mean LVEF 54 ± 6%; 75% had LVEF >50%]. Eighteen percent had non-sustained VTs and 37% had atrial fibrillation on Holter monitoring. During a median follow-up of 657 (219-748) days, the primary endpoint of sustained VT was observed in one patient. The incidence of the primary endpoint was 0.6 (95% confidence interval 0.2-3.5) per 100 person-years. The incidence of the secondary endpoint of non-sustained VT was 11.5 (7.1-18.7) per 100 person-years. Five patients develope...Continue Reading

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Citations

Jan 27, 2021·European Heart Journal·Michiel Rienstra, Isabelle C Van Gelder
Jan 20, 2021·European Journal of Heart Failure·Daniela TomasoniMarco Metra
May 2, 2021·European Journal of Heart Failure·Bart A MulderMichiel Rienstra
Aug 10, 2021·Frontiers in Cardiovascular Medicine·Kaiyuan ZhuDachun Xu

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Methods Mentioned

BETA
coronary artery bypass

Clinical Trials Mentioned

NCT01989299

Software Mentioned

SPSS
R
epiR

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