PMID: 9435625Jan 22, 1998Paper

Ventricular-vascular uncoupling by acute conotruncal occlusion in the stage 21 chick embryo

The American Journal of Physiology
B B KellerJoseph P Tinney

Abstract

Embryonic ventricular diastolic and systolic function was evaluated during normal ejection (coupled) and during acute ventricular outflow tract occlusion (uncoupled) in the stage 21 chick embryo. We simultaneously measured ventricular pressure with a servo-null system and ventricular dimensions using video microscopy. Experimental protocols included 1) baseline recording followed by acute conotruncal (CT) ligation (n = 15) and 2) baseline recording, preload increase using Krebs-Henseleit buffer (3 microliters), preload reduction via venous hemorrhage, and then CT occlusion (n = 20). Ventricular epicardial cross-sectional area was converted to internal volume using wall volume measures and assuming an ellipsoid geometry to produce pressure-volume loops. We calculated the time constant of ventricular pressure decline using a monoexponential decay function with a pressure asymptote. As previously noted, heart rate was unaffected by acutely altered preload or afterload. CT ligation increased end-systolic pressure, maximal +dP/dt, and the time constant of ventricular pressure decline and decreased stroke volume indexed for end-diastolic volume. Thus the embryonic ventricle has significant contractile reserve masked in vivo by the dy...Continue Reading

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Citations

Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K Tobita, B B Keller
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Kimimasa TobitaBradley B Keller
Aug 21, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Warren BurggrenTiffany Sun
May 28, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Liang ShiSandra Rugonyi
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K Tobita, B B Keller
Jul 12, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Christine E MillerDavid Sedmera
May 2, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jennifer L LucittiBradley B Keller
Dec 21, 2012·Biomechanics and Modeling in Mechanobiology·Christine M BuffintonDavid Sedmera
Dec 10, 2020·Journal of Cardiovascular Development and Disease·Warren Burggren, Maria Rojas Antich
May 10, 2005·The Journal of Experimental Biology·Jennifer L LucittiBradley B Keller

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