Ventricular Zone Disruption in Human Neonates With Intraventricular Hemorrhage

Journal of Neuropathology and Experimental Neurology
James P McAllisterDavid D Limbrick

Abstract

To determine if ventricular zone (VZ) and subventricular zone (SVZ) alterations are associated with intraventricular hemorrhage (IVH) and posthemorrhagic hydrocephalus, we compared postmortem frontal and subcortical brain samples from 12 infants with IVH and 3 nonneurological disease controls without hemorrhages or ventriculomegaly. Birth and expiration estimated gestational ages were 23.0-39.1 and 23.7-44.1 weeks, respectively; survival ranges were 0-42 days (median, 2.0 days). Routine histology and immunohistochemistry for neural stem cells (NSCs), neural progenitors (NPs), multiciliated ependymal cells (ECs), astrocytes (AS), and cell adhesion molecules were performed. Controls exhibited monociliated NSCs and multiciliated ECs lining the ventricles, abundant NPs in the SVZ, and medial vs. lateral wall differences with a complex mosaic organization in the latter. In IVH cases, normal VZ/SVZ areas were mixed with foci of NSC and EC loss, eruption of cells into the ventricle, cytoplasmic transposition of N-cadherin, subependymal rosettes, and periventricular heterotopia. Mature AS populated areas believed to be sites of VZ disruption. The cytopathology and extension of the VZ disruption correlated with developmental age but not...Continue Reading

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Citations

May 9, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Richard F KeepGuohua Xi
Nov 4, 2017·Journal of Neuropathology and Experimental Neurology
Feb 3, 2018·Fluids and Barriers of the CNS·Richard F KeepLester R Drewes
May 1, 2019·Journal of Neuropathology and Experimental Neurology·Leandro Castañeyra-RuizIbrahim González-Marrero
Jul 23, 2018·Journal of Neuropathology and Experimental Neurology·Leandro Castaneyra-RuizDavid D Limbrick
Jun 1, 2020·Stem Cells Translational Medicine·Beatriz Fernández-MuñozRosario Sanchez-Pernaute
Aug 2, 2020·Fluids and Barriers of the CNS·Longbing MaFengzeng Jian
Mar 11, 2020·Nature Reviews. Neurology·Jason K KarimyKristopher T Kahle
Feb 18, 2020·Cell and Tissue Research·Roberto HenziMontserrat Guerra
Jul 22, 2020·Fluids and Barriers of the CNS·Leandro Castaneyra-RuizDavid D Limbrick
Sep 2, 2020·Nature Communications·Zsófia I LászlóIstván Katona
Jan 25, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Xinhai Robert ZhangHarry V Vinters
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Dec 18, 2020·The Journal of Cell Biology·Masataka KuniiAkihiro Harada
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Jul 1, 2021·Neuropediatrics·Hans C LudwigSteffi Dreha-Kulaczewski
Jul 16, 2021·Journal of Applied Physiology·Jeff F Dunn, Albert M Isaacs

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