Ventrolateral medulla in spontaneously hypertensive rats: role of angiotensin II

The American Journal of Physiology
H MurataniD B Averill

Abstract

We investigated whether angiotensin II (ANG II), endogenous to the ventrolateral medulla (VLM), contributes to cardiovascular regulation in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. The action of ANG II endogenous to the VLM was examined by microinjection of 100 pmol of [Sar1,Thr8]ANG II into either the rostral (R) or caudal (C) VLM. This ANG II antagonist caused depressor and bradycardic responses in the RVLM and pressor and tachycardic responses in the CVLM. The magnitude of the blood pressure responses was significantly greater (P < 0.01 in RVLM and P < 0.05 in CVLM) in SHRs (-27 +/- 3 mmHg in RVLM and 29 +/- 4 mmHg in CVLM) than in WKY rats (-17 +/- 1 and 17 +/- 2 mmHg, respectively). Suppression of tonic activity of RVLM neurons by bilateral injection of muscimol in the RVLM showed that the pressor response produced by ANG II antagonist injection in the CVLM required the integrity of rostral pressor neurons. The present data suggest that ANG II endogenous to RVLM and CVLM acts as a tonic excitatory agent on vasomotor neurons of the VLM. The contribution of ANG II in the RVLM and CVLM to the prevailing level of blood pressure was significantly (P < 0.01) larger in SHRs vs. WKY rats when...Continue Reading

Citations

Feb 24, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·O BaltatuM Bader
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A C AlzamoraM J Campagnole-Santos
Apr 2, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick J Mueller
Nov 28, 2013·Journal of Hypertension·Kristy L JacksonGeoffrey A Head
May 20, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Yang-Kai WangWei-Zhong Wang
Nov 5, 2019·Frontiers in Physiology·Kristy L JacksonFrancine Z Marques
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P D PottsR A Dampney
May 27, 2010·Journal of Hypertension·Alain G Dupont, Sofie Brouwers
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Chang-zhen RenYang-kai Wang
Apr 8, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kayla D RoweMark M Knuepfer
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Sep 14, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Keisuke ShinoharaKenji Sunagawa

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