Ventrolateral Motor Thalamus Abnormal Connectivity in Essential Tremor Before and After Thalamotomy: A Resting-State Functional Magnetic Resonance Imaging Study

World Neurosurgery
Constantin TuleascaDimitri Van De Ville

Abstract

To evaluate functional connectivity (FC) of the ventrolateral thalamus, a common target for drug-resistant essential tremor (ET), resting-state data were analyzed before and 1 year after stereotactic radiosurgical thalamotomy and compared against healthy controls (HCs). In total, 17 consecutive patients with ET and 10 HCs were enrolled. Tremor network was investigated using the ventrolateral ventral (VLV) thalamic nucleus as the region of interest, extracted with automated segmentation from pretherapeutic diffusion magnetic resonance imaging. Temporal correlations of VLV at whole brain level were evaluated by comparing drug-naïve patients with ET with HCs, and longitudinally, 1 year after stereotactic radiosurgical thalamotomy. 1 year thalamotomy MR signature was always located inside VLV and did not correlate with any of FC measures (P > 0.05). This suggested presence of longitudinal changes in VLV FC independently of the MR signature volume. Pretherapeutic ET displayed altered VLV FC with left primary sensory-motor cortex, pedunculopontine nucleus, dorsal anterior cingulate, left visual association, and left superior parietal areas. Pretherapeutic negative FC with primary somatosensory cortex and pedunculopontine nucleus corr...Continue Reading

Citations

Jul 25, 2019·Human Brain Mapping·Julián Benito-LeónNorberto Malpica
Dec 17, 2019·Human Brain Mapping·Constantin TuleascaDimitri Van De Ville
Dec 14, 2018·Journal of Neurosurgery·Veronica L ChiangArjun Sahgal
May 18, 2019·Journal of Neurosurgery·Constantin TuleascaDimitri Van De Ville
Apr 24, 2020·Molecular Psychiatry·Milagros Hidalgo de la CruzMaria A Rocca

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