Ventromedial hypothalamus suppresses splenic lymphocyte activity through sympathetic innervation

Brain Research
S OkamotoM Saito

Abstract

The ventromedial hypothalamic nucleus (VMH) has been proposed to be a locus intimately associated with sympathetic facilitation in peripheral tissues. To investigate a possible role of the VMH in controlling peripheral immune functions, we examined the effects of VMH stimulation on proliferative activity of lymphocytes isolated from the spleen in rats. Electrical stimulation of the VMH (2 s at every 30 s for 30 min) caused a remarkable decrease in the mitogenic response of splenic lymphocytes to Concanavalin A, whereas the stimulation of other hypothalamic regions such as the paraventricular nucleus did not show any significant effects. The suppressive effect of VMH stimulation was not influenced after adrenalectomy, suggesting a minor role of the adrenocortical system. In contrast, pretreatments with a ganglionic blocking agent (chlorisondamine) and a beta-adrenergic receptor antagonist (propranolol) completely reversed the suppressive effect. Surgical severing of the sympathetic nerves entering the spleen also reversed the effect of VMH stimulation. Together with the previous finding that VMH stimulation activates the splenic sympathetic nerves, it is concluded that the VMH suppresses the proliferative activity of splenic lym...Continue Reading

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Citations

Jan 7, 2004·Biological Psychology·Tokiko IsowaSeikou Murashima
Feb 15, 2014·Autonomic Neuroscience : Basic & Clinical·Wilfrid Jänig
Sep 11, 2003·Journal of Neuroimmunology·Danuta Wrona, Weronika Trojniar
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Sep 9, 2020·Nature Reviews. Cancer·Kenichiro Kinouchi, Paolo Sassone-Corsi
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Oct 16, 2019·Frontiers in Endocrinology·Natalie K Y WeeErica L Scheller
Mar 9, 2021·Autonomic Neuroscience : Basic & Clinical·Wei-Xing PanSarah Faggert Alemi

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