VenUS II: a randomised controlled trial of larval therapy in the management of leg ulcers.

Health Technology Assessment : HTA
Jo DumvilleVenUS II team

Abstract

To compare the clinical effectiveness and cost-effectiveness of larval therapy with a standard debridement technique (hydrogel). A pragmatic, three-arm, randomised controlled trial with an economic evaluation. Community nursing services, community leg ulcer clinics and hospital outpatient leg ulcer clinics. A range of urban and rural settings. Patients with venous or mixed venous/arterial ulcers (minimum ankle brachial pressure index of 0.6) where a minimum of 25% of ulcer area was covered by slough and/or necrotic material. Loose larval therapy and bagged larval therapy compared with hydrogel. The primary end point was complete healing of the largest eligible ulcer. The primary outcome was time to complete healing of the reference ulcer. Secondary outcomes were: time to debridement, cost of treatments, health-related quality of life (including ulcer-related pain), bacterial load, presence of methicillin-resistant Staphylococcus aureus and staff and patient attitudes to and beliefs about larval therapy. Between July 2004 and May 2007 the trial recruited 267 people aged 20-94 years at trial entry. There were more female (n = 158) than male (n = 109) participants and most ulcers were classified by the nurse as having an area grea...Continue Reading

Citations

Mar 24, 2009·BMJ : British Medical Journal·Marta O SoaresUNKNOWN VenUS II team
Feb 11, 2012·Journal of Biomolecular NMR·Mads Kristian Erlin NygaardReinhard Wimmer
Sep 6, 2015·Diabetes/metabolism Research and Reviews·F L GameUNKNOWN International Working Group on the Diabetic Foot
Jan 3, 2014·Asian Journal of Surgery·Chumpon WilasrusmeeAmmarin Thakkinstian
Jun 27, 2012·Clinics in Plastic Surgery·Ian C Hoppe, Mark S Granick
Apr 22, 2011·The British Journal of Surgery·L-H ChuangUNKNOWN VenUS III team
Jul 16, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Silvan KleinLukas Prantl
Jun 8, 2013·Dermatologic Therapy·Jennifer Gloeckner PowersTania J Phillips
Oct 15, 2013·Lancet·James Raftery, John Powell
Jan 16, 2016·The Cochrane Database of Systematic Reviews·Gill NormanNicky Cullum
Dec 16, 2016·The Cochrane Database of Systematic Reviews·Maggie J WestbyNicky Cullum
Dec 6, 2014·British Journal of Community Nursing·Eric Shi, David Shofler
Jun 16, 2018·The Cochrane Database of Systematic Reviews·Gill NormanJo C Dumville
Sep 1, 2015·Applied Health Economics and Health Policy·Catherine MeadsLouise Longworth
Feb 11, 2012·Biotechnology Progress·David I PritchardWalter Low
Sep 2, 2018·The Cochrane Database of Systematic Reviews·Maggie J WestbyRichard D Riley
Aug 18, 2010·Wiener medizinische Wochenschrift·Pietro NenoffJan Christoph Simon
Jul 28, 2019·Medical and Veterinary Entomology·F Stadler
Dec 5, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Elizabeth MudgeKeith G Harding
Mar 14, 2020·British Journal of Nursing : BJN·Yaping LianManj Gohel
Aug 23, 2020·International Journal of Environmental Research and Public Health·Mohd Zurairie Mohd ZubirNorhayati Mohd Noor
Jul 10, 2010·Journal of Wound Care·R AshbyJ Watson
Feb 16, 2013·Deutsches Ärzteblatt International·Mike RüttermannMarion Burckhardt

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