PMID: 8607661Apr 1, 1996Paper

Verapamil as prophylactic treatment for atrial fibrillation after lung operations

The Annals of Thoracic Surgery
W Van MieghemM G Demedts

Abstract

Atrial fibrillation is a frequently occurring arrhythmia after thoracic operations. Preventive strategies for this complication have been extensively evaluated after cardiac operations. We performed a prospective, open randomized study, comparing intravenous verapamil and placebo in 199 patients after pneumonectomy or lobectomy at the University Hospital of Leuven. Verapamil was administered as a bolus of 10 mg over 2 minutes followed by a 30-minute infusion of 0.375 mg/min and then 0.125 mg/min for 3 days. The patients were continuously monitored in the postoperative intensive care unit. Atrial fibrillation occurred in 15% of the patients receiving placebo and in 8% of the patients receiving verapamil (difference not significant). The verapamil infusion was interrupted in 9% of the patients because of bradycardia and in 14% because of hypotension. If tolerated, continuous intravenous verapamil infusion showed only a modest prophylactic efficacy for the occurrence of atrial fibrillation after lung operations. In the dose employed the verapamil infusion was accompanied with a high incidence of side effects necessitating interruption of the therapy.

Citations

Mar 7, 2008·Surgical Endoscopy·Kiran K TuragaSumeet K Mittal
Oct 31, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Joel DunningUNKNOWN EACTS Audit and Guidelines Committee
May 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·Artyom SedrakyanJan van der Meulen
Apr 10, 2003·The Annals of Thoracic Surgery·Koen De DeckerPaul Van Schil
Aug 23, 2003·Anesthesia and Analgesia·Duminda N Wijeysundera, W Scott Beattie
Nov 16, 2013·Anesthesiology Research and Practice·George VretzakisMetaxia Bareka
Dec 10, 1999·The Annals of Thoracic Surgery·D CardinaleM Mezzetti
Oct 7, 2014·The Annals of Thoracic Surgery·Lars Peter RiberThomas Decker Christensen
Aug 9, 2001·Seminars in Thoracic and Cardiovascular Surgery·M H Kim, K A Eagle
Nov 24, 2011·Thoracic Surgery Clinics·Robert E Merritt, Joseph B Shrager
Jan 1, 2010·Seminars in Thoracic and Cardiovascular Surgery·James E TisdaleKenneth A Kesler
Apr 16, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Solomon Aronson, Joseph Varon
Sep 29, 2006·Thoracic Surgery Clinics·John M KaramichalisEric S Lambright
Aug 26, 1998·Journal of Cardiothoracic and Vascular Anesthesia·M BäcklundL Lindgren
Dec 17, 1998·Journal of Cardiothoracic and Vascular Anesthesia·S M NeusteinE Cohen
Mar 23, 1999·The Annals of Thoracic Surgery·C D BayliffR S Kennedy
Aug 25, 2009·The Annals of Thoracic Surgery·James E TisdaleKenneth A Kesler
Dec 3, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Di AiUNKNOWN Outcomes Research Consortium
Oct 29, 1998·Chest·S E KopecA A Conlan
Sep 26, 2000·The Journal of Thoracic and Cardiovascular Surgery·D AmarR J Ginsberg
Jun 28, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·P CiriacoP Zannini
Jan 19, 2016·Journal of Cardiovascular Pharmacology·Liangze Zhang, Shugeng Gao
Feb 23, 2019·Nature Reviews. Cardiology·Dobromir DobrevStanley Nattel
Jul 19, 2020·World Journal of Surgery·Hironori IshibashiKenichi Okubo
May 16, 2019·Intensive Care Medicine·Mik WetterslevMorten Hylander Møller
Feb 21, 2006·World Journal of Gastroenterology : WJG·Jian-Yang MaJun-Jie Yang
Dec 28, 2019·Journal of Clinical Medicine·Iacopo FabianiDaniela Maria Cardinale
Jan 18, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Ciara HanleyPeter Slinger
Sep 22, 2001·The Medical Clinics of North America·S B Sloan, H H Weitz
Nov 18, 2000·Current Problems in Surgery·A T PezzellaA A Conlan
Aug 28, 2021·Cancers·Gennaro Carmine SemeraroDaniela Maria Cardinale
Aug 24, 2021·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Jianqi HaoLunxu Liu

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