Verapamil disposition and cardiovascular effects in elderly patients after single intravenous and oral doses

Cardiovascular Drugs and Therapy
L CarosellaP U Carbonin

Abstract

Pharmacokinetics and pharmacodynamics of verapamil were studied in 11 elderly subjects (age = 79.67 +/- 4.74 years) and in 11 middle-aged subjects (age = 45 +/- 11.37 years) following intravenous (IV), single oral, and long-term oral administration. Plasma verapamil concentrations were determined using high-pressure liquid chromatography (HPLC). Twenty-four hour dynamic Holter electrocardiographic (ECG) recordings were employed to study heart rate (HR) and P-R interval. No difference in plasma half-life, distribution volume, body clearance, and area under the curve (AUC) was observed between the two groups after IV and oral verapamil administration. Blood pressure (BP) and HR were significantly reduced after verapamil IV administration in the elderly group only (p less than 0.05, p less than 0.01, respectively). After single and long-term oral administration, variable HR and BP responses were observed in both groups. The P-R prolongation following both IV and single oral doses exhibited a delay with respect to the peak plasma concentration, inducing a definite hysteresis loop. The slope of P-R variations (using a linear pharmacodynamic model) was greater in the elderly both after IV and single oral verapamil administration, but...Continue Reading

References

Jun 1, 1979·Clinical Pharmacology and Therapeutics·B CusackJ Horgan
Mar 1, 1978·Clinical and Experimental Pharmacology & Physiology·K HotraphinyoA Maclaine-Cross
Jan 1, 1979·Journal of Clinical Pharmacology·S M MacLeodE M Sellers
Jun 1, 1977·British Journal of Clinical Pharmacology·A M ShepherdI H Stevenson
Sep 1, 1976·Cardiovascular Research·M SchomerusM Eichelbaum
Nov 1, 1986·Lancet·G Tognoni, M Bonati
Mar 28, 1987·Lancet·P U CarboninR Bernabei
Aug 1, 1987·Journal of the American College of Cardiology·J A HerdR Harris
Dec 1, 1987·Clinical Pharmacology and Therapeutics·F E Young
Jan 1, 1986·Therapeutic Drug Monitoring·D J GreenblattR I Shader
Jan 1, 1986·European Journal of Clinical Pharmacology·P AndersonU de Faire
Aug 1, 1985·Annals of Internal Medicine·A W ZimmerD Kaye
Jan 1, 1985·European Journal of Clinical Pharmacology·R PadriniM Ferrari
Jul 1, 1971·Circulation·B Lown, M Wolf
Jan 1, 1972·The American Journal of Cardiology·E Simonson
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·H BartelsC Heierli
Sep 1, 1970·Metabolism: Clinical and Experimental·G B Forbes, J C Reina
Apr 1, 1969·Circulation·G A EwyF I Marcus
Jan 1, 1981·Journal of Cardiovascular Pharmacology·J A DominicR G McAllister
Nov 1, 1983·Journal of Gerontology·G A BorkanC K Silbert
Apr 1, 1982·Clinical Pharmacology and Therapeutics·R G McAllister, E B Kirsten
Jan 1, 1982·European Journal of Clinical Pharmacology·P AndersonC Sylvén
Dec 1, 1982·Clinical Pharmacology and Therapeutics·M J ReiterE L Pritchett
Sep 1, 1981·The American Journal of Cardiology·S BachmanL K Smith
Sep 1, 1981·British Journal of Clinical Pharmacology·A JohnstonJ Hamer

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Citations

Mar 28, 2001·Journal of Clinical Pharmacology·J B Schwartz
May 1, 2008·Future Cardiology·Sandra A Jones, Matthew K Lancaster
Nov 13, 2007·The American Journal of Geriatric Pharmacotherapy·Mark W Bowie, Patricia W Slattum
Jun 10, 1998·Regulatory Toxicology and Pharmacology : RTP·A G Renwick, N R Lazarus
Aug 5, 2011·Drugs & Aging·Vera H M Deneer, Norbert M van Hemel

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