Verapamil-induced behavioral, autonomic and motor effects in cats

Pharmacology, Biochemistry, and Behavior
D B BeleslinB Terzić

Abstract

The effects of verapamil, a calcium antagonist, injected into the cerebral ventricles on behavior, autonomic and motor activity of unanesthetized cats have been investigated. Verapamil evoked emotional behavior (miaowing and alertness), autonomic responses (mydriasis, tachypnoea, dyspnoea, defecation, micturition, licking and panting) and motor phenomena (ataxia, muscular weakness and adynamia). These effects lasted from a few minutes to several hours. The most consistent phenomena were miaowing, alertness, mydriasis and respiratory irregularities. The possible mechanism of action of verapamil on behavior, autonomic and motor activity may be an action on voltage-operated calcium channels in the brain.

References

Jan 1, 1977·Annual Review of Pharmacology and Toxicology·A Fleckenstein
Aug 1, 1978·The American Journal of Psychiatry·Y D Lapierre
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R J GouldS H Snyder
Dec 31, 1957·The Journal of Physiology·W FELDBERG, S L SHERWOOD

Citations

May 1, 1995·Drug and Alcohol Dependence·H J Little
Jan 1, 1989·Fundamental & Clinical Pharmacology·C Damase-MichelP Montastruc

Related Concepts

Metazoa
Autonomic Nervous System
Felis catus
Regret
Injections, Intraventricular
Finoptin

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