Veratric Acid Inhibits LPS-Induced IL-6 and IL-8 Production in Human Gingival Fibroblasts

Inflammation
Qi-Bao WangYi Du

Abstract

Veratric acid, one of the major benzoic acid isolated from vegetables and fruits, has been reported to have anti-inflammatory activity. The purpose of this study was to investigate the anti-inflammatory effects of veratric acid on lipopolysaccharide (LPS)-induced inflammatory response in human gingival fibroblasts (HGFs). HGFs were pretreated with veratric acid 1 h before LPS stimulation. The productions of IL-6 and IL-8 were detected by ELISA. The expression of iNOS, COX-2, PI3K, AKT, and NF-κB were detected by western blotting. The results showed that veratric acid inhibited LPS-induced IL-6 and IL-8 production, as well as iNOS and COX-2 expression. Veratric acid also inhibited LPS-induced NF-κB activation. In addition, veratric acid was found to suppress LPS-induced PI3K and AKT phosphorylation. In conclusion, the anti-inflammatory mechanism of veratric acid is due to its ability to inhibit PI3K/Akt/NF-κB signaling pathway.

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Citations

Jun 18, 2017·Journal of Periodontal Research·X YuS Li
Mar 6, 2018·Proteomics. Clinical Applications·Lian GuiJunqi Huang
Apr 2, 2021·Chronobiology International·Ahmet Özer SehirliNurettin Abacioglu
Dec 30, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Arunkumar RamuTheerthu Azamuthu
Nov 2, 2021·Frontiers in Cell and Developmental Biology·Jian ChenQian Qu

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